Chemical exchange saturation transfer fingerprinting for exchange rate quantification

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Zhengwei ZhouDebiao Li

Abstract

There is an increased interest to determine the exchange rate using CEST to provide pH information. However, current CEST quantification methods require lengthy scan times and do not address magnetization transfer effects. The purpose of this work was to apply the magnetic resonance fingerprinting (MRF) concept to CEST to achieve more efficient and accurate exchange rate quantification. The proposed CEST fingerprinting method used varying saturation powers and saturation times to create unique signal evolutions for different exchange rates. The acquired signal was matched to a predefined dictionary to determine the exchange rate. The magnetization transfer effects were also addressed in the framework of CEST fingerprinting: The simulated dictionary could predict the signal curves without magnetization transfer effects, and comparing the dictionary to the acquired signals allowed the correction of the magnetization transfer effects. The CEST fingerprinting method was compared with the conventional pulsed quantitative CEST method using omega plots in the creatine phantom study. The CEST fingerprinting method has a significantly reduced scan time (10 minutes versus 50 minutes) while providing more accurate exchange rate quantifica...Continue Reading

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Citations

Mar 6, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Eleni DemetriouXavier Golay
Aug 11, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Or PerlmanChristian T Farrar
Nov 26, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tom HilbertMartijn A Cloos
Jul 3, 2019·Journal of Magnetic Resonance Imaging : JMRI·Megan E PoormanKathryn E Keenan
Jan 4, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yuguang MengPhillip Zhe Sun
Jul 28, 2019·Journal of Magnetic Resonance Imaging : JMRI·Debra F McGivneyDan Ma
Jan 22, 2019·Journal of Magnetic Resonance Imaging : JMRI·Jinyuan ZhouShanshan Jiang
Nov 15, 2020·Journal of Magnetic Resonance Imaging : JMRI·Sooyeon JiKoung Mi Kang
May 27, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Charit TippareddyChaitra Badve
Jul 24, 2021·Current Opinion in Chemical Biology·Peter C M van ZijlLinda Knutsson
Nov 10, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jie LiuYin Wu

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