Chemical exposure levels in printing workers with cholangiocarcinoma (second report)

Journal of Occupational Health
Kenichi YamadaGinji Endo

Abstract

In several Japanese printing plants, printing workers have suffered from cholangiocarcinoma. 1,2-dichloropropane (1,2-DCP) is considered to be a causative agent, and whether or not other chemicals also contribute to the development of this disease has not been conclusively determined. This study aimed to identify the chemicals used by seven printing workers who developed cholangiocarcinoma, as well as to estimate the levels of chemical exposure among them. Information was obtained from the Ministry of Health, Labour and Welfare, Japan, to identify chemicals used by printing workers who developed cholangiocarcinoma and to estimate chemical exposure concentrations. Working environment concentrations of the chemicals in the printing rooms were estimated using a well-mixed model, and exposure concentrations during the ink removal operation were estimated using a near-field and far-field model. Shift time-weighted averages of exposure concentrations were also calculated. Four of the seven printing workers were exposed to both 1,2-DCP and dichloromethane (DCM). The estimated maximum exposure concentrations for each of the four workers were 230 to 420 ppm for 1,2-DCP and 58 to 720 ppm for DCM, and the estimated shift average exposure ...Continue Reading

References

Aug 1, 1990·Scandinavian Journal of Work, Environment & Health·S F LanesK J Soden
Jun 1, 1996·American Industrial Hygiene Association Journal·M Nicas
Aug 30, 2005·Journal of Epidemiology·Tsuyoshi MatsubaUNKNOWN JACC Study Group
Mar 16, 2013·Occupational and Environmental Medicine·Shinji KumagaiGaku Ichihara
Jan 15, 2014·Journal of Hepato-biliary-pancreatic Sciences·Shoji KuboGinji Endo
Jul 30, 2014·Journal of Occupational Health·Kenichi YamadaGinji Endo

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Citations

Jul 2, 2016·Journal of Hepato-biliary-pancreatic Sciences·Shoji KuboYasuni Nakanuma
Jul 6, 2018·Industrial Health·Kyeong Min KwakSeong-Kyu Kang
Apr 19, 2018·Health and Quality of Life Outcomes·Kalkidan TemesgenCheru Tesema Leshargie
Jun 5, 2018·Annals of Gastroenterological Surgery·Shoji KuboTakanori Aota
Jul 1, 2020·Clinical Pathology·Bita Geramizadeh
Jan 3, 2021·Regulatory Toxicology and Pharmacology : RTP·Wolfgang DekantJosje Arts

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