Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways

Toxicological Sciences : an Official Journal of the Society of Toxicology
Allan Peter DavisCarolyn J Mattingly

Abstract

The Comparative Toxicogenomics Database (CTD; http://ctdbase.org) is a public resource that manually curates the scientific literature to provide content that illuminates the molecular mechanisms by which environmental exposures affect human health. We introduce our new chemical-phenotype module that describes how chemicals can affect molecular, cellular, and physiological phenotypes. At CTD, we operationally distinguish between phenotypes and diseases, wherein a phenotype refers to a nondisease biological event: eg, decreased cell cycle arrest (phenotype) versus liver cancer (disease), increased fat cell proliferation (phenotype) versus morbid obesity (disease), etc. Chemical-phenotype interactions are expressed in a formal structured notation using controlled terms for chemicals, phenotypes, taxon, and anatomical descriptors. Combining this information with CTD's chemical-disease module allows inferences to be made between phenotypes and diseases, yielding potential insight into the predisease state. Integration of all 4 CTD modules furnishes unique opportunities for toxicologists to generate computationally predictive adverse outcome pathways, linking chemical-gene molecular initiating events with phenotypic key events, adve...Continue Reading

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Citations

Apr 18, 2019·Environmental Health Perspectives·Jean-Charles CarvailloKarine Audouze
Oct 10, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marylène RugardKarine Audouze
Feb 29, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jonathan A HollanderChristine Ladd-Acosta
Jul 7, 2019·Pathology Oncology Research : POR·Dongyun HeMinjia Sheng
Jul 15, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Allan Peter DavisCarolyn J Mattingly
Jan 4, 2020·Environmental Health Perspectives·Felicia CastriotaJen-Chywan Wang
Sep 25, 2018·Nucleic Acids Research·Allan Peter DavisCarolyn J Mattingly
Oct 18, 2020·Nucleic Acids Research·Allan Peter DavisCarolyn J Mattingly
Dec 7, 2019·Chemical Research in Toxicology·Zhichao LiuWeida Tong

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