Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models

Epilepsia
A A ShandraR S Vastyanov

Abstract

The efficacy of phenobarbital (PB) and phenytoin (PHT) was evaluated against the convulsions in chemically (picrotoxin, PTX) kindled rats. Two protocols were used: assessment of seizures immediately after the completion of the kindling procedure and after the 2-week postkindling PTX-free period, as compared with acute PTX seizures. Kindled convulsions were more sensitive than acute PTX seizures to the antiepileptic action of PB and PHT. On the other hand, the "postkindling state" was characterized by the enhancement of the severity of the convulsions in comparison with both kindled and acute PTX seizures and dramatic increase in the resistance to the action of antiepileptic drugs (AEDs). It is concluded that the two paradigms--kindling proper and "postkindling"--could be applied as models for AED-sensitive and AED-resistant animal epilepsy models correspondingly.

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Citations

Jun 30, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·A I Brusentsov
Mar 14, 2013·Bulletin of Experimental Biology and Medicine·L S GodlevskyV A Polyasnyi
Jun 24, 1998·Epilepsia·A B EttingerB P Hermann
Feb 14, 2012·The Journal of Pharmacology and Experimental Therapeutics·Dorota ZolkowskaMichael A Rogawski
Jul 12, 2012·Psychopharmacology·Patrícia Xavier L GomesDanielle S Macêdo
Mar 14, 2007·Current Opinion in Neurology·Scott C Baraban
Feb 1, 2005·Pharmacology, Biochemistry, and Behavior·Karthik Rajasekaran
Aug 22, 2006·Journal of Ethnopharmacology·P ZanoliM Baraldi
Apr 29, 2005·Neuropharmacology·Jesper F BastlundWilliam P Watson
Feb 8, 2018·Developmental Neurobiology·Marcela LaukováMichael P Shakarjian
Oct 19, 2017·Archives of Toxicology·Brandon PresslyHeike Wulff
Aug 6, 2019·Epilepsy & Behavior : E&B·Daniel Pérez-PérezLuisa Rocha

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