Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation

Annual Review of Physical Chemistry
Thomas C T MichaelsTuomas P J Knowles

Abstract

Understanding how normally soluble peptides and proteins aggregate to form amyloid fibrils is central to many areas of modern biomolecular science, ranging from the development of functional biomaterials to the design of rational therapeutic strategies against increasingly prevalent medical conditions such as Alzheimer's and Parkinson's diseases. As such, there is a great need to develop models to mechanistically describe how amyloid fibrils are formed from precursor peptides and proteins. Here we review and discuss how ideas and concepts from chemical reaction kinetics can help to achieve this objective. In particular, we show how a combination of theory, experiments, and computer simulations, based on chemical kinetics, provides a general formalism for uncovering, at the molecular level, the mechanistic steps that underlie the phenomenon of amyloid fibril formation.

References

Jul 1, 1975·Journal of Theoretical Biology·F Oosawa
Apr 10, 1992·Science·J A Hardy, G A Higgins
Jun 25, 1985·Journal of Molecular Biology·F A FerroneW A Eaton
Sep 2, 1999·Trends in Biochemical Sciences·C M Dobson
Feb 12, 2000·Biochimica Et Biophysica Acta·E RhoadesA Gafni
Sep 12, 2000·FEBS Letters·V A IconomidouS J Hamodrakas
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J E PodrabskyS C Hand
Jul 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·José L JiménezHelen R Saibil
Sep 16, 2003·Neuron·William Dauer, Serge Przedborski
Dec 20, 2003·Nature·Dennis J Selkoe
Dec 20, 2003·Nature·Fred E Cohen, Jeffery W Kelly
Jan 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christopher P JaroniecRobert G Griffin
Nov 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Thorsten LührsRoland Riek
Nov 24, 2005·The FEBS Journal·O Sumner Makin, Louise C Serpell
May 18, 2006·Annual Review of Microbiology·Michelle M Barnhart, Matthew R Chapman
Jun 8, 2006·Annual Review of Biochemistry·Fabrizio Chiti, Christopher M Dobson
Jan 26, 2007·Current Opinion in Structural Biology·Ravindra Kodali, Ronald Wetzel
Feb 9, 2007·Journal of Neurochemistry·Dominic M Walsh, Dennis J Selkoe
Feb 23, 2007·The Journal of Biological Chemistry·Jonghee OhIngyu Hwang
Apr 7, 2007·Trends in Biochemical Sciences·Douglas M FowlerJeffery W Kelly
May 1, 2007·Nature·Michael R SawayaDavid Eisenberg
May 17, 2007·IUBMB Life·Sergio T FerreiraFernanda G De Felice
May 29, 2007·Cellular and Molecular Life Sciences : CMLS·M Fändrich
Aug 2, 2007·EMBO Reports·Elodie Monsellier, Fabrizio Chiti
Sep 19, 2007·Micron : the International Research and Review Journal for Microscopy·Margaret SundeJoel P Mackay
Dec 17, 2008·Biochimica Et Biophysica Acta·Aimee M MorrisRichard G Finke
Jan 29, 2009·The Journal of Chemical Physics·Jianing Zhang, M Muthukumar
Feb 4, 2009·Angewandte Chemie·Bruno BulicEckhard Mandelkow
Feb 18, 2009·Journal of Alzheimer's Disease : JAD·Hozefa Amijee, David I C Scopes
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ryan P McGlincheyReed B Wickner
Dec 17, 2009·Science·Tuomas P J KnowlesChristopher M Dobson
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Diego RomeroRoberto Kolter
Mar 2, 2010·Nature Nanotechnology·Tuomas P J KnowlesMark E Welland
Mar 2, 2010·Nature Reviews. Drug Discovery·Adriano Aguzzi, Tracy O'Connor
Jul 9, 2010·Lancet Neurology·Francesca MangialascheMiia Kivipelto
Jan 18, 2011·Chemical Communications : Chem Comm·Chaoxu LiRaffaele Mezzenga
Mar 5, 2011·Current Opinion in Structural Biology·Chun Wu, Joan-Emma Shea

❮ Previous
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Citations

Jul 7, 2018·Chemical Communications : Chem Comm·Mattias TörnquistSara Linse
Feb 12, 2019·Scientific Reports·Thomas SkamrisBente Vestergaard
Apr 3, 2019·Cold Spring Harbor Perspectives in Biology·Christopher M DobsonMichele Vendruscolo
Mar 18, 2020·Microscopy Research and Technique·Giuseppe SancataldoValeria Vetri
Mar 14, 2020·Angewandte Chemie·Fabian SoltermannWeston B Struwe
Mar 22, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ariel M AlpersteinMartin T Zanni
May 16, 2019·ELife·Christoph WeberL Mahadevan
Jun 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Thomas C T MichaelsL Mahadevan
Apr 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Zhiguang JiaJianhan Chen
Apr 15, 2020·Nature Chemistry·Thomas C T MichaelsTuomas P J Knowles
May 22, 2020·The Journal of Biological Chemistry·Jobst LiebauLena Mäler
Sep 26, 2020·Scientific Reports·Yue YuCarter T Butts
Sep 13, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ruben D EliasLalit Deshmukh
Mar 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zaida L Almeida, Rui M M Brito
Aug 12, 2020·Nature Structural & Molecular Biology·Patrick FlagmeierChristopher M Dobson
Jul 25, 2019·Physical Review. E·Thomas C T MichaelsTuomas P J Knowles
Feb 3, 2020·The Journal of Chemical Physics·Alexander J DearTuomas P J Knowles
Jul 17, 2020·The Journal of Chemical Physics·Alexander I P TaylorRosemary A Staniforth
Sep 16, 2020·Proceedings of the National Academy of Sciences of the United States of America·Thomas C T MichaelsTuomas P J Knowles
Feb 4, 2021·ACS Chemical Neuroscience·Yehong GongQingwen Zhang
Feb 3, 2021·Biophysical Chemistry·Fulvio Grigolato, Paolo Arosio
Jan 25, 2020·Journal of Molecular Graphics & Modelling·S MuscatA Danani
Mar 10, 2020·Journal of Molecular Biology·José Angel Fernández-HigueroJose M G Vilar
Oct 15, 2020·International Journal of Molecular Sciences·Tomas SneiderisVytautas Smirnovas
Mar 16, 2021·Frontiers in Neuroscience·Tatsuya IkenoueMichele Vendruscolo
Apr 4, 2021·International Journal of Molecular Sciences·Filipe E P RodriguesMiguel Machuqueiro
Mar 2, 2021·Chembiochem : a European Journal of Chemical Biology·Marielle A WältiG Marius Clore
Apr 6, 2021·ACS Omega·Chandra Mouli R MadhuranthakamPraveen P N Rao
Jan 10, 2020·Current Opinion in Structural Biology·Govardhan ReddyBalaka Mondal
Nov 5, 2019·Current Opinion in Structural Biology·Rodrigo GallardoSheena E Radford
May 8, 2021·The Journal of Physical Chemistry. B·Aditi SharmaAndreas S Bommarius
Apr 23, 2021·Chembiochem : a European Journal of Chemical Biology·Reza MalekiMohammad-Ali Shahbazi
Jun 18, 2021·Chemical Reviews·Dieter WillboldHenrike Heise
Jul 6, 2021·The Journal of Biological Chemistry·Mara ZielinskiGunnar F Schröder
Jul 6, 2021·Journal of Molecular Biology·Roy NassarKen A Dill
Jul 6, 2021·Journal of Molecular Biology·Liisa LutterWei-Feng Xue

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Methods Mentioned

BETA
nuclear magnetic resonance
nuclear
circular dichroism
fluorescence microscopy
NMR
X-ray
biosensing

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