Chemical lesion of visceral afferents causes transient overconsumption of unfamiliar high-fat diets in rats

The American Journal of Physiology
M ChavezH R Berthoud

Abstract

Because it is commonly assumed that the major role of visceral afferents in food intake control is to terminate meals by carrying negative-feedback signals to the brain, we hypothesized that overconsumption should occur in rats with chemically lesioned visceral afferents if they were presented with an unfamiliar diet. Adult male Sprague-Dawley (SD) rats were treated with multiple doses of capsaicin or vehicle as a control. Five weeks later, a series of 3-h feeding tests after 24-h deprivation was carried out, first with chow and then with either a solid (vegetable shortening) or liquid (Ensure) unfamiliar high-fat diet. Both groups consumed similar amounts of their powdered chow maintenance diet, but capsaicin-treated rats consumed at least 50% more of either high-fat diet than vehicle controls (P < 0.01) at the beginning of the first trial. During second and third trials with the now-familiar high-fat diet, intake was no longer significantly different between the two groups, suggesting rapid engagement of redundant control mechanisms. These results support a role of capsaicin-sensitive visceral afferents in providing negative feedback for early meal termination during the ingestion of unfamiliar diets.

Citations

Feb 7, 2001·Annual Review of Psychology·S C WoodsR J Seeley
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L KellyH R Berthoud
Mar 17, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicholas T Bello, Timothy H Moran
Apr 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Terry L PowleyRobert J Phillips
Jul 22, 2016·Nutritional Neuroscience·María A ZafraAmadeo Puerto
Dec 18, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Huiyuan ZhengHans-Rudolf Berthoud
Sep 27, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Edward A FoxJennifer McAdams

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