Nov 1, 1975

Chemical modification of carboxyl groups of fibrinogen and its effect on the binding of cationic detergent

Journal of Biochemistry
S KuriokaM Matsuda

Abstract

Carboxyl groups of native human fibrinogen were modified with glycine methyl ester and 1-ethyl-3(3-dimethylaminopropyl)carbodiimide. It seemed likely that the modification occurred stepwise. Approximately 26% of the carboxyl groups of fibrinogen was modified finally. The modified fibrinogen had no interaction with cationic detergent, and did not form any complex with the detergent. In dilute acid, fibrinogen was observed to show only a slight interaction with cationic detergent. It is probable that the exposed and ionized carboxyl groups are essential for the formation of a complex between fibrinogen and cationic detergent.

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Mentioned in this Paper

Structure-Activity Relationship
Fibrinogen
Fibrinogen Assay
Glycine
Plasma Protein Binding Capacity
Glycine (Plant)
Carbodiimides
Fibrinogen Complex Location
Fibrinogen Activity
Esters

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