Chemical Modifications in the Life of an mRNA Transcript.

Annual Review of Genetics
Sigrid Nachtergaele, Chuan He

Abstract

Investigations over the past eight years of chemical modifications on messenger RNA (mRNA) have revealed a new level of posttranscriptional gene regulation in eukaryotes. Rapid progress in our understanding of these modifications, particularly, N6-methyladenosine (m6A), has revealed their roles throughout the life cycle of an mRNA transcript. m6A methylation provides a rapid mechanism for coordinated transcriptome processing and turnover that is important in embryonic development and cell differentiation. In response to cellular signals, m6A can also regulate the translation of specific pools of transcripts. These mechanisms can be hijacked in human diseases, including numerous cancers and viral infection. Beyond m6A, many other mRNA modifications have been mapped in the transcriptome, but much less is known about their biological functions. As methods continue to be developed, we will be able to study these modifications both more broadly and in greater depth, which will likely reveal a wealth of new RNA biology.

References

Jun 15, 1977·Journal of Molecular Biology·K Beemon, J Keith
Nov 1, 1976·Journal of Virology·S I Hashimoto, M Green
Oct 1, 1975·Nucleic Acids Research·D T Dubin, R H Taylor
Sep 1, 1990·Molecular and Cellular Biology·S M CarrollF M Rottman
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R DesrosiersF Rottman
Jun 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M EdmondsH Nakazato
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S HorowitzF M Rottman
Aug 15, 1998·The Journal of Biological Chemistry·R C PillutlaA J Shatkin
Oct 29, 1998·Biochemical and Biophysical Research Communications·T TsukamotoK Mizumoto
Dec 18, 2007·Molecular Cell·Ulrike BegleyThomas J Begley
Apr 2, 2008·Current Opinion in Microbiology·Estella M GustiloPaul F Agris
Dec 9, 2008·Nucleic Acids Research·Matthias SchaeferFrank Lyko
Nov 17, 2010·Nature Chemical Biology·Chuan He
Oct 18, 2011·Nature Chemical Biology·Guifang JiaChuan He
Feb 22, 2012·Nucleic Acids Research·Jeffrey E SquiresThomas Preiss
May 12, 2012·Nature·Dan DominissiniGideon Rechavi
Aug 23, 2012·Development·Caroline MedioniFlorence Besse
Apr 23, 2013·Nature Biotechnology·Vahid Khoddami, Bradley R Cairns
Nov 30, 2013·Genome Biology·Shobbir HussainMichaela Frye
Dec 10, 2013·Nature Chemical Biology·Jianzhao LiuChuan He
Dec 18, 2013·Journal of the American Chemical Society·Emily M HarcourtEric T Kool
Jun 7, 2014·Frontiers in Genetics·Hiroyuki Hori

❮ Previous
Next ❯

Citations

Aug 28, 2019·Cell & Bioscience·Jiashuo LiYu Deng
Apr 16, 2020·BMC Biology·Ulrike SchumannThomas Preiss
Apr 10, 2020·The Journal of Biological Chemistry·Magda BujnowskaJingyi Fei
Sep 24, 2020·The EMBO Journal·Lingling WangTariq M Rana
Feb 20, 2019·Frontiers in Genetics·Dirk H Ostareck, Antje Ostareck-Lederer
Dec 6, 2019·Nature Reviews. Neuroscience·Ido LivnehDan Dominissini
Apr 29, 2020·Nature Chemical Biology·Ye WangGuifang Jia
Aug 8, 2019·Cell Research·Yifei GaoPilong Li
Mar 27, 2020·Experimental & Molecular Medicine·Sung Ho Boo, Yoon Ki Kim
Sep 13, 2020·International Journal of Molecular Sciences·Crescenzio Francesco MinerviniFrancesco Albano
Jun 17, 2020·Plant & Cell Physiology·Xuan MaWeijiang Luan
Jan 9, 2020·Nucleic Acids Research·Sanqi AnJinkai Wang
May 15, 2020·Experimental & Molecular Medicine·Seung Hun Han, Junho Choe
May 29, 2020·Journal of Molecular Cell Biology·Marion AlriquetR Martin Vabulas
Sep 26, 2020·Nucleic Acids Research·Virginie MarchandYuri Motorin
Oct 14, 2020·Molecular Microbiology·Amir Mossanen-ParsiMark X Caddick
Nov 12, 2020·Molecular Biology Reports·R KarthiyaPiyush Khandelia
Mar 22, 2019·Cancer Research·Qing LanTao Liu
Dec 12, 2020·Computational and Structural Biotechnology Journal·Sajid AhmedAbdollah Dehzangi
Sep 11, 2019·Molecular Metabolism·Dario F De Jesus, Rohit N Kulkarni
Jan 24, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jing HeFucheng He
Jul 8, 2020·Annual Review of Nutrition·Xin Erica ShuShu-Bing Qian
Dec 15, 2020·Nucleic Acids Research·Stephan WernerMark Helm
Feb 16, 2021·Chemical Communications : Chem Comm·Siying XiangJianzhao Liu
Feb 24, 2021·RNA Biology·Lukasz MarkiewiczPawel J Sikorski
Apr 15, 2021·Cell Metabolism·Harini RamalingamVishal Patel
Mar 25, 2019·Methods : a Companion to Methods in Enzymology·Marie FlammeMarcel Hollenstein
Apr 24, 2021·Zygote : the Biology of Gametes and Early Embryos·Tong YuYunhai Zhang
Feb 6, 2021·Annual Review of Immunology·Qian Zhang, Xuetao Cao
Apr 30, 2021·Frontiers in Immunology·Yinong ChaoJing Zhou
Jun 8, 2021·Frontiers in Cell and Developmental Biology·Danae Campos-MeloMichael J Strong
Jun 12, 2021·Cell·Matthew D Disney
Jun 22, 2021·Frontiers in Cell and Developmental Biology·Jiahui LuoKai Sun
Jul 24, 2021·Trends in Genetics : TIG·Ryan L KanTamer Sallam

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
chemical modifications
chemical modification
GTPase
PCR
immunoprecipitation

Software Mentioned

TGIRT

Related Concepts

Related Feeds

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.