Chemical priming of immunity without costs to plant growth

The New Phytologist
Will BuswellJurriaan Ton

Abstract

β-Aminobutyric acid (BABA) induces broad-spectrum disease resistance, but also represses plant growth, which has limited its exploitation in crop protection. BABA perception relies on binding to the aspartyl-tRNA synthetase (AspRS) IBI1, which primes the enzyme for secondary defense activity. This study aimed to identify structural BABA analogues that induce resistance without stunting plant growth. Using site-directed mutagenesis, we demonstrate that the (l)-aspartic acid-binding domain of IBI1 is critical for BABA perception. Based on interaction models of this domain, we screened a small library of structural BABA analogues for growth repression and induced resistance against biotrophic Hyaloperonospora arabidopsidis (Hpa). A range of resistance-inducing compounds were identified, of which (R)-β-homoserine (RBH) was the most effective. Surprisingly, RBH acted through different pathways than BABA. RBH-induced resistance (RBH-IR) against Hpa functioned independently of salicylic acid, partially relied on camalexin, and was associated with augmented cell wall defense. RBH-IR against necrotrophic Plectosphaerella cucumerina acted via priming of ethylene and jasmonic acid defenses. RBH-IR was also effective in tomato against Botr...Continue Reading

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Citations

Sep 1, 2019·Annual Review of Phytopathology·Samuel W WilkinsonJurriaan Ton
Nov 22, 2018·Frontiers in Plant Science·Mian Zhou, Wei Wang
Sep 27, 2018·Plants·Pierre PétriacqEstrella Luna
Dec 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nathalie GuarnizoMaría Bianney Bermúdez-Cardona
Sep 11, 2020·Journal of Experimental Botany·Vasvi ChaudhryEric Kemen
Feb 4, 2021·Trends in Plant Science·Jonas De KeselTina Kyndt
Mar 18, 2021·Pest Management Science·Mustafa YassinAdrian C Newton
Aug 29, 2021·Plants·Alfonso Gonzalo De la RubiaPenélope García-Angulo

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