Chemical profiles, pharmacological properties, and in silico studies provide new insights on Cycas pectinata

Heliyon
Abu Montakim TareqTalha Bin Emran

Abstract

The current study aimed to qualitatively and quantitatively determine the phytochemical components of Cycas pectinata methanol extract (MECP), along with its antioxidant, anti-inflammatory, thrombolytic, locomotor, anxiolytic, analgesic, and antidiarrheal activities. The in vitro antioxidant activity was evaluated by DPPH scavenging assay and the total phenol and total flavonoid contents, while the anti-inflammatory activity was evaluated by a protein denaturation assay. The in vivo locomotor effects were examined using the open field test and hole-cross test. The anxiolytic effect was examined using the elevated plus maze (EPM) test, hole-board test (HBT), and light-dark test (LDT), while the analgesic activity was investigated using the acetic acid-induced writhing test. The antidiarrheal effect was evaluated by castor oil-induced diarrhea and gastrointestinal motility. Ten bioactive compounds were selected on the basis of their biological activities and further investigated using in silico molecular docking simulation to correlate with the identified pharmacological properties. Additionally, the ADME properties of the compounds were evaluated according to their drug-likeness profile. MECP had a maximum total phenol content o...Continue Reading

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Citations

Aug 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Israt JahanJesus Simal-Gandara
Sep 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmed RakibJesus Simal-Gandara
Feb 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Md Zia UddinJesus Simal-Gandara
Nov 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Naureen BanuJesus Simal-Gandara
Jan 12, 2021·Saudi Journal of Biological Sciences·Bishwajit GuhaAli M Alqahtani
May 1, 2021·Plants·Md Masudur RahmanJesus Simal-Gandara
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rajib DasMohammad S Mubarak
Feb 5, 2022·Drug and Chemical Toxicology·Chuckles Ch MarakVikas Kumar Roy

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Methods Mentioned

BETA
motility test

Software Mentioned

Schrödinger
GraphPad Prism
QikProp
Schrödinger Maestro

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