Chemical profiling, in vitro antioxidant, membrane stabilizing and antimicrobial properties of wild growing Murraya paniculata from Amarkantak (M.P.).

Scientific Reports
Shruti SonterPrashant Kumar Singh

Abstract

The excessive usage of antibiotics in humans and veterinary medicine has lead to the emergence of antibiotic resistance and now requires the use of novel antibiotics. There has been increased interest towards plants as source of drugs because of their pharmacological potency and long traditional usage. The aim of the current study was to evaluate bioactive components, antioxidant, and anti-inflammatory activities of the leaf extracts of Murraya paniculata, a plant traditionally used in Indian medicinal system. Evaluations were made for phytochemical analysis, antioxidant, membrane stabilizing, and antimicrobial activities. The methanol extract displayed the highest flavonoid and phenolic content, the acetone extract demonstrated considerable ABTS inhibitory activity (IC50value:555.18 ± 1.68 µg/mL) and the hexane extract exhibited highest H2O2 radical scavenging activity (IC50value: 509.84 ± 3.03 µg/mL). The aqueous extract displayed 19.4 ± 0.66% RBC hemolysis and 80.5 ± 0.66% protection caused by hypotonic solution at high concentration of the extract. The fractions of hexane extract revealed a higher zone of inhibition than crude extract. The major components found in the fractions were cyclohexane (40.11%) and 3-(6-Methoxy-3-...Continue Reading

References

Jun 1, 1988·Antimicrobial Agents and Chemotherapy·W J LloydP Wong-Kai-In
Jul 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B HalliwellO I Aruoma
Oct 1, 1996·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·A Sofowora
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Nov 24, 1999·Journal of Agricultural and Food Chemistry·I F Benzie, Y T Szeto
Mar 17, 2005·Journal of Agricultural and Food Chemistry·Jun YuBhimanagouda S Patil
Dec 3, 2005·International Journal of Antimicrobial Agents·T P Tim Cushnie, Andrew J Lamb
Dec 27, 2007·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Jm Conly, Bl Johnston
Jan 15, 2007·Talanta·D VillañoM C García-Parrilla
Aug 10, 2010·Critical Reviews in Food Science and Nutrition·J CôtéM Lacroix
Sep 21, 2010·Bioorganic & Medicinal Chemistry Letters·Chung-Kyu RyuAram Kim
Dec 15, 2010·International Journal of Molecular Sciences·Yu-Fen ChenYu-Chun Huang
Jul 13, 2011·International Journal of Molecular Sciences·Rudi HendraEhsan Oskoueian
Nov 19, 2011·Pharmacognosy Reviews·Maheep K ChaharYogesh C Joshi
Feb 26, 2013·International Journal of Molecular Sciences·Cecilia BrunettiMassimiliano Tattini
Dec 7, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jingtao ZouDayuan Sui
Jan 29, 2014·TheScientificWorldJournal·Shashank Kumar, Abhay K Pandey
Jul 21, 2014·Breast Cancer Research and Treatment·Sébastien CouraudLaurent Azoulay
Aug 19, 2014·International Journal of Antimicrobial Agents·T P Tim CushnieAndrew J Lamb
Mar 11, 2015·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Olusola Olalekan Elekofehinti
Sep 12, 2015·BMC Complementary and Alternative Medicine·Fatima SaqibMuhammad Zia-Ul-Haq
May 27, 2016·Microbiology Spectrum·Jose M Munita, Cesar A Arias
Jun 2, 2016·Advances in Pharmacological Sciences·Mona GhasemianMohammad Bagher Owlia
Nov 3, 2016·Oxidative Medicine and Cellular Longevity·Palanisamy ArulselvanS Suresh Kumar
Jul 1, 2017·Journal of Integrative Medicine·Pragya SharmaAnupam Sharma
Dec 22, 2017·Germs·Siti-Noor-Adnalizawati AdnanWan Ahmad Yaacob
Jan 18, 2018·Recent Patents on Inflammation & Allergy Drug Discovery·Mohd I YatooHafiz M N Iqbal
Feb 3, 2018·Aging and Disease·Supakanya WongrakpanichJanani Rangaswami
May 8, 2018·Clinical Interventions in Aging·Ilaria LiguoriPasquale Abete
Jul 10, 2018·Current Medicinal Chemistry·Ana María González-ParamásCelestino Santos-Buelga

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