Chemical Profiling of Medical Cannabis Extracts

ACS Omega
Melissa M LewisLakshmi P Kotra

Abstract

Medical cannabis has been legally available for patients in a number of countries. Licensed producers produce a variety of cannabis strains with different concentrations of phytocannabinoids. Phytocannabinoids in medical cannabis are decarboxylated when subjected to heating for consumption by the patients or when extracted for preparing cannabis derivative products. There is little understanding of the true chemical composition of cannabis extracts, changes occurring during heating of the extracts, and their relevance to pharmacological effects. We investigated the extract from a popular commercial strain of medical cannabis, prior to and after decarboxylation, to understand the chemical profiles. A total of up to 62 compounds could be identified simultaneously in the extract derived from commercial cannabis, including up to 23 phytocannabinoids. Upon heating, several chemical changes take place, including the loss of carboxylic group from the acidic phytocannabinoids. This investigation attempts to reveal the chemical complexity of commercial medical cannabis extracts and the differences in the chemical composition of the native extract and the one subjected to heat. Comprehensive chemical analyses of medical cannabis extracts...Continue Reading

References

Jun 1, 1968·Chemical & Pharmaceutical Bulletin·Y ShoyamaI Nishioka
Oct 4, 2005·Life Sciences·Mahmoud A Elsohly, Desmond Slade
Feb 20, 2008·Planta medica·Mohamed M RadwanMahmoud A Elsohly
Feb 29, 2008·Journal of Natural Products·Safwat A AhmedM A ElSohly
Sep 9, 2008·Phytochemistry·Mohamed M RadwanSamir A Ross
Apr 7, 2009·Journal of Natural Products·Mohamed M RadwanSamir A Ross
Jun 13, 2009·Recent Patents on CNS Drug Discovery·Ahmed M GalalMahmoud A Elsohly
Jan 19, 2010·Drug and Alcohol Review·Eric J Downer, Veronica A Campbell
Feb 2, 2010·Chemical & Pharmaceutical Bulletin·Justin FischedickRobert Verpoorte
Mar 1, 2012·Drug Testing and Analysis·A Hazekamp, J T Fischedick
Jun 19, 2012·Cellular & Molecular Biology Letters·Monika StyrczewskaJan Szopa
Oct 30, 2012·Reviews in the Neurosciences·Antonia ManducaViviana Trezza
Oct 24, 2014·Analytical and Bioanalytical Chemistry·Oier Aizpurua-OlaizolaAresatz Usobiaga
May 23, 2015·Journal of Natural Products·Mohamed M RadwanSamir A Ross
Jun 21, 2015·Phytochemistry·Safwat A AhmedMahmoud A ElSohly
Sep 24, 2015·Nature·Brian Owens
Oct 11, 2016·Natural Product Reports·Lumír Ondřej HanušGiovanni Appendino

❮ Previous
Next ❯

Citations

May 31, 2020·Regional Anesthesia and Pain Medicine·Hance ClarkeLakshmi P Kotra
Sep 29, 2019·Cannabis and Cannabinoid Research·Melissa M Lewis-BakkerLakshmi P Kotra
Dec 25, 2019·Cannabis and Cannabinoid Research·Karim S LadhaHance Clarke
Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yi YangLakshmi P Kotra
Oct 4, 2019·Cannabis and Cannabinoid Research·Marcel O Bonn-MillerDonald Abrams
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Nov 28, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Samridhi LalSubash C Gupta
Jan 22, 2021·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Namkee G ChoiS David Baker
Nov 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Taja ŽitekMaša Knez Hrnčič
Mar 17, 2021·Journal of Cannabis Research·M Nazir TahirJohn F Trant
May 15, 2021·Journal of Pharmaceutical and Biomedical Analysis·Simona PiccolellaSeverina Pacifico
Apr 19, 2019·ACS Medicinal Chemistry Letters·Michele ProttiLaura Mercolini
Aug 17, 2021·Journal of Clinical Pharmacology·Joshua D BrownAmie J Goodin
Sep 3, 2021·Journal of Pharmaceutical and Biomedical Analysis·Miriam StempferHerbert Oberacher
Sep 23, 2021·Cannabis and Cannabinoid Research·Crist N Filer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
J S Jones
The American Journal of Nursing
M L Mathre
Journal of Opioid Management
Gilbert J Fanciullo
© 2022 Meta ULC. All rights reserved