Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol

Frontiers in Chemistry
Chiara CassianoMaria Chiara Monti

Abstract

Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-β1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-β1 translocation has been evaluated by in vitro assays.

References

Feb 11, 2005·Traffic·Lucy F Pemberton, Bryce M Paschal
Apr 5, 2007·Nature Protocols·Andrej ShevchenkoMatthias Mann
Jan 1, 2009·International Journal of Cancer. Journal International Du Cancer·Pauline J van der WattVirna D Leaner
Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Brett LomenickJing Huang
Sep 18, 2010·Journal of Chemical Information and Modeling·Jacob D Durrant, J Andrew McCammon
Sep 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jui-Lung ShenYung-Hsiang Chen
Feb 1, 2011·Pharmacology & Therapeutics·Young-Jung LeeJin Tae Hong
Aug 15, 2012·Journal of Cheminformatics·Marcus D HanwellGeoffrey R Hutchison
Feb 19, 2013·Angewandte Chemie·Slava ZieglerHerbert Waldmann
Aug 22, 2013·Chemical Communications : Chem Comm·Chiara CassianoMaria Chiara Monti
Apr 29, 2014·Chemical Communications : Chem Comm·C CassianoM C Monti
Jan 27, 2015·Methods in Molecular Biology·Melody Y PaiJing Huang
Apr 15, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Matteo MozzicafreddoMauro Angeletti
Jun 9, 2016·Acta Neuropathologica·Steven BoeynaemsLudo Van Den Bosch
Jul 27, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jia ShenMeichun Hu
Feb 8, 2018·Current Opinion in Cell Biology·Tolga Çağatay, Yuh Min Chook
Jun 24, 2018·Bioorganic & Medicinal Chemistry·Simone Di MiccoGiuseppe Bifulco
Oct 31, 2018·Chemical Communications : Chem Comm·Federica Del GaudioMaria Chiara Monti

❮ Previous
Next ❯

Methods Mentioned

BETA
Seq
GTPase

Software Mentioned

PoseView
Mascot
PyMOL Molecular Graphics System
Avogadro
DARTS
PyMol
converter
MS
Autodock Vina
NNscore

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.