Chemical reaction monitoring using zero-field nuclear magnetic resonance enables study of heterogeneous samples in metal containers

Angewandte Chemie
Dudari B. BuruevaDmitry Budker

Abstract

We demonstrate that heterogeneous/biphasic chemical reactions can be monitored with high spectroscopic resolution using zero-field nuclear magnetic resonance. This is possible because magnetic susceptibility broadening is negligible at ultralow magnetic fields. We show the two-step hydrogenation of dimethyl acetylenedicarboxylate with para-enriched hydrogen gas in conventional glass NMR tubes, as well as in a titanium tube. The low frequency zero-field NMR signals ensure that there is no significant signal attenuation due to shielding by the electrically conductive sample container. This method paves the way for in situ monitoring of reactions in complex heterogeneous multiphase systems and in reactors made from conductive materials while maintaining resolution and chemical specificity.

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Citations

Jan 16, 2021·Analytical Chemistry·Piotr PutDanila A Barskiy
Feb 2, 2021·Journal of Magnetic Resonance·John W BlanchardAndreas Trabesinger
Apr 8, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Eduard Y ChekmenevIgor V Koptyug
Apr 17, 2021·The Journal of Chemical Physics·Ivan V ZhukovKonstantin L Ivanov
Apr 8, 2021·Magnetic Resonance in Chemistry : MRC·John W BlanchardDmitry Budker
Aug 3, 2021·Physical Chemistry Chemical Physics : PCCP·Ben J TicknerVille-Veikko Telkki
Jan 8, 2021·The Journal of Physical Chemistry Letters·Seyma AlcicekSzymon Pustelny
Oct 28, 2021·The Journal of Physical Chemistry Letters·Seyma AlcicekSzymon Pustelny

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR

Software Mentioned

PHIP

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