Chemical risk assessment and uncertainty associated with extrapolation across exposure duration

Regulatory Toxicology and Pharmacology : RTP
H R PohlJ S Holler

Abstract

The Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on priority substances in which available epidemiologic and toxicologic data are reviewed, summarized, and interpreted. When adequate data are available, ATSDR derives health guidance values called minimal risk levels (MRLs) for acute, intermediate, and chronic durations of exposure for oral and inhalation routes of exposure. The MRLs are generally derived by use of the no-observed-adverse-effect level (NOAEL) or the lowest-observed-adverse-effect level/uncertainty factor (LOAEL/UF) approach. The UF usually employed are for LOAEL-to-NOAEL extrapolation, animal to -human extrapolation, and inter-human variability. These health guidance values are intended to serve as screening tools for health assessors and other responders to identify contaminants of concern and potential health effects in the community at hazardous waste sites and during unplanned releases. When guidance values are not available for a specific exposure scenario because of a lack of chronic data, extrapolation across exposure durations may be made. For example, chronic guidance values may be derived from subchronic data by applying an additional uncertainty factor of 10...Continue Reading

References

Jan 1, 1992·Immunopharmacology and Immunotoxicology·P MeeraO Tripathi
Jan 1, 1992·Neurotoxicology and Teratology·E S Goldey, D H Taylor
Jan 1, 1973·Anesthesia and Analgesia·A A SmithA B Glassman
Nov 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R M Fay, M M Mumtaz
May 16, 1997·Toxicology·E Benfenati, G Gini
May 23, 2002·International Journal of Hygiene and Environmental Health·C H Selene J ChouChristopher T De Rosa
Dec 4, 2004·Science·Qing LanMartyn T Smith
Dec 30, 2006·Regulatory Toxicology and Pharmacology : RTP·H G AbadinF T Llados
Dec 1, 2004·Drug Discovery Today. Technologies·Romualdo Benigni

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Citations

Oct 15, 2013·Environmental Science and Pollution Research International·Uwe Schneider
Sep 10, 2013·Regulatory Toxicology and Pharmacology : RTP·Benoît SchilterAndrew Worth
Jul 4, 2012·Regulatory Toxicology and Pharmacology : RTP·H R PohlM M Mumtaz
Oct 30, 2016·Regulatory Toxicology and Pharmacology : RTP·Liesbeth GeraetsWouter Ter Burg
Jul 31, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patricia RuizMoiz Mumtaz
Feb 20, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Manon Pruvost-CouvreurGilles Rivière
Oct 1, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sabine GuthJürg A Zarn

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