PMID: 7993552Jun 1, 1994Paper

Chemical sensors and biosensors for fluoride: current status and developing technologies

Advances in Dental Research
J S Schultz


Portable sensors for bioanalytes are becoming of increasing interest, because their development will permit analyses of biological samples at the point of sampling, i.e., at the time when an individual is being examined by a health professional. In this paper, the design requirements for a fluoride sensor are outlined. Currently, commercially available fluoride sensors, ion-selective electrodes, do provide the capability to measure fluoride content in samples directly. However, the sensitivity of these devices is lower than the normal content of fluoride in plasma, and thus, samples must be concentrated before measurement. Recent progress in improving the sensitivity of chemical sensors for fluoride shows sensitivities up to 0.1 mumol/L, which is within the range of interest. In addition, the use of biological systems for developing sensors (biosensors) is expanding rapidly, because of the potential of achieving high selectivity and sensitivity through the use of the amplification power of enzymes. However, relatively few enzyme systems have been discovered that are affected by fluoride--thus the need for expanded research to find appropriate enzymes for this purpose. The characteristics of some enzymes, such as adenylate cycla...Continue Reading


Apr 23, 1976·Biochimica Et Biophysica Acta·S B RodanR I Sha'afi
Aug 1, 1991·Scientific American·J S Schultz
Feb 1, 1990·Journal of Dentistry·J E TylerK L Kong
Dec 1, 1986·Journal of Bioenergetics and Biomembranes·J D RobinsonM Steinberg
Sep 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M W LundyD J Baylink
Aug 24, 1966·Biochimica Et Biophysica Acta·A OmachiE Gerlach
Oct 31, 1962·Annals of the New York Academy of Sciences·L C CLARK, C LYONS
Feb 1, 1988·Talanta·R NarayanaswamyF Sevilla

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