Chemical sensory deafferentation abolishes hypothalamic pituitary activation induced by noxious stimulation or electroacupuncture but only decreases that caused by immobilization stress. A c-fos study

Neuroscience
B PanA Coimbra

Abstract

We have shown in previous c-fos studies that noxious stimulation or electroacupuncture in deeply anaesthetized rats activate the hypothalamic pituitary corticotrope axis in a specific way. C-fos expression was more pronounced in the arcuate than the paraventricular hypothalamic nuclei, and none occurred in the pituitary intermediate lobe. The absence of the usual autonomic responses to psychological stress, such as tachycardia or blood pressure elevation, suggested a specific action of the somatosensory input on the hypothalamic pituitary axis. To prove this hypothesis, c-fos expression was examined in the paraventricular, arcuate and other hypothalamic nuclei, the pituitary gland, and the A1 and A2 medullary catecholaminergic cell groups of animals deprived of nociceptive primary afferent input by neonatal capsaicin. After noxious stimulation or electroacupuncture, no c-fos enhancement occurred in any of those sites in capsaicin-treated animals, and there was no increased plasma release of adrenocorticotropic hormone. In contrast, the hypothalamic pituitary c-fos activation provoked by immobilization stress though markedly decreased, was not abolished by capsaicin, whereas plasma release of adrenocorticotropic hormone remained...Continue Reading

References

Oct 15, 1979·European Journal of Pharmacology·P HolzerF Lembeck
Jan 22, 1992·The Journal of Comparative Neurology·G Battaglia, A Rustioni
Jan 15, 1990·The Journal of Comparative Neurology·R BursteinG J Giesler
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S CeccatelliT Hökfelt
Sep 1, 1989·The Journal of Endocrinology·M S Harbuz, S L Lightman
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T NakaneC S Hollander
Apr 1, 1987·British Journal of Pharmacology·R Amann, F Lembeck
Jan 1, 1984·Annual Review of Neuroscience·A I Basbaum, H L Fields
Mar 31, 1980·Brain Research·J I NagyH I Yamamura

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Citations

Apr 15, 2010·Glycoconjugate Journal·Mayuko IwamotoToshihiko Kadoya
Jun 6, 2003·Neuroscience and Biobehavioral Reviews·Terence V Sewards, Mark A Sewards
Dec 11, 2002·The European Journal of Neuroscience·Lingling Zhu, Tatsushi Onaka
Jan 7, 2005·The American Journal of Chinese Medicine·Hye-Jung LeeInsop Shim
Jan 30, 2008·Anesthesia and Analgesia·Shu-Ming WangPaul White
Feb 7, 2013·The Journal of Endocrinology·Ladan EshkevariSusan E Mulroney
Apr 22, 2010·Neurological Research·Asterios KaragiannisVasilios G Athyros
Dec 10, 1998·Journal of Neuroimmunology·N E SaadéB Safieh-Garabedian
Mar 4, 2011·British Journal of Pharmacology·M M B RibeiroM Castanho
Oct 23, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Zheng-Ying QiuMing-Xing Ding
Jul 20, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Man-Li HuMing-Xing Ding
Dec 11, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M A MedeirosL E A M Mello
Jun 28, 2008·Progress in Neurobiology·Zhi-Qi Zhao
Jul 14, 2018·The American Journal of Chinese Medicine·Yuan XuGuangchang Pang
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S M MorinJ A DiMicco
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A VallèsA Armario

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