Chemical shift imaging for evaluation of adrenal masses: a systematic review and meta-analysis

European Radiology
Ivan PlatzekRalf-Thorsten Hoffmann

Abstract

To perform a systematic review and meta-analysis of published data to evaluate the utility of chemical shift imaging (CSI) for differentiating between adrenal adenomas and non-adenomas. A systematic search of the MEDLINE, Web of Science Core Collection, EMBASE and Cochrane Central Register of Controlled Trials electronic databases was performed. The methodological quality of the included studies was assessed by using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies) tool. A bivariate random effect model was used to determine summary and subgroup sensitivity and specificity and calculate summary receiver operating characteristic curves (SROC). Eighteen studies with 1138 patients and 1280 lesions (859 adenomas, 421 non-adenomas) in total were included. In addition to summary analysis, quantitative analyses of the adrenal signal intensity index (SII, 978 lesions, 14 studies), adrenal-to-spleen ratio (ASR; 394 lesions, 7 studies) and visual analysis (560 lesions, 5 studies) were performed. The resultant data showed considerable heterogeneity (inconsistency index I2 of 94%, based on the diagnostic odds ratio, DOR). The pooled sensitivity of CSI for adenoma was 0.94 [95% confidence interval (CI) 0.88-0.97] and pooled s...Continue Reading

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Citations

Sep 24, 2020·Endocrine·Fatih EkerZeynep Rumeysa Celik
Jan 7, 2020·Abdominal Radiology·Gonçalo Freire, Miguel Ramalho
Apr 9, 2020·Endocrine Reviews·Mark SherlockPaul M Stewart
Jan 11, 2020·Abdominal Radiology·Daniel I Glazer, William W Mayo-Smith
Apr 22, 2021·The New England Journal of Medicine·Electron Kebebew
Mar 21, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Urszula Ambroziak
Jun 1, 2021·Radiologic Clinics of North America·Daniel I GlazerWilliam W Mayo-Smith

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