PMID: 2496250Mar 1, 1989Paper

Chemical stability of selenious acid in total parenteral nutrition solutions containing ascorbic acid

JPEN. Journal of Parenteral and Enteral Nutrition
H E Ganther, R J Kraus

Abstract

Reduction of selenious acid (H2SeO3) to elemental Se by ascorbic acid was investigated in regard to the stability of selenite in total parenteral nutrition (TPN) solutions. [75Se] H2SeO3 (100 micrograms Se/liter) was incubated at 25 degrees C with pure ascorbic acid (100 or 500 mg/liter) or added to complete TPN solutions containing similar levels of ascorbate. The mixtures were subjected to thin layer electrophoresis at pH 5.3 to separate HSeO3- from Se degree. In complete TPN formulas, little or no reduction of HSeO3- to Se degree occurred over a 24-hr period, whereas complete reduction occurred with pure ascorbic acid. Further experiments showed that the amino acid component of the TPN formula was preventing the reduction of selenite, and that reduction of selenite by ascorbate did not occur in buffered solutions having a pH of 5 or greater. These results show that reduction of selenite is strongly influenced by pH. At the concentrations of H2SeO3 and ascorbic acid commonly used, reduction to elemental Se is unlikely to be a practical problem in TPN solutions in the near-neutral pH range.

References

Oct 1, 1979·The American Journal of Clinical Nutrition·A M van RijM F Robinson
May 1, 1978·The American Journal of Clinical Nutrition·N L ZabelH E Ganther
Sep 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·C D McGeeK N Jeejeebhoy
Feb 1, 1983·The American Journal of Clinical Nutrition·C L Kien, H E Ganther
May 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·C R FlemingJ Petz
May 14, 1981·The New England Journal of Medicine·R A JohnsonH J Cohen

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Citations

Oct 16, 1992·Pharmaceutisch Weekblad. Scientific Edition·M C Allwood, M Greenwood
Oct 1, 1994·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·C C Romeo, P Jones
Jun 1, 1997·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·A TeradaK Yoshida
Jun 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·L Gallitelli
Sep 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·E B Cochran, K A Boehm
Oct 18, 2000·British Journal of Nursing : BJN·L Russell
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·G Hardy, C Reilly
Nov 18, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Joseph I BoullataUNKNOWN ASPEN Parenteral Nutrition Safety Committee

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