Chemical structure and anti-inflammatory effect of polysaccharide extracted from Morinda citrifolia Linn (Noni)

Carbohydrate Polymers
Stefany Guimarães SousaAndré Luiz Dos Reis Barbosa

Abstract

Polysaccharides extracted from plants are very promising molecules in the field of pharmacotherapy. Knowing this, the aim of this study was to extract, characterize and evaluate the action of the polysaccharide of Morinda citrifolia Linn (Noni-PLS) in biological models of inflammatory processes. The characterization tests shown that sample refers to a heteropolysaccharide composed mainly of homogalacturonan and rhamnogalacturonan. This polysaccharide at dose of 10 mg/kg, when tested in our models of inflammation, showed significant activity in reducing carrageenan-induced paw oedema as well as all mediators edemas. This polysaccharide was able to inhibit the migration of leukocytes to the site of inflammation, and still reduced inflammatory nociception tests. This results, allows us to conclude that the polysaccharide extracted from Morinda citrifolia linn has anti-inflammatory potential since it reversed inflammatory parameters such as edema, leukocyte migration and nociception.

Citations

Dec 17, 2019·Phytotherapy Research : PTR·Bharat Singh, Ram A Sharma
Jun 20, 2019·Frontiers in Bioengineering and Biotechnology·Shuixan Hu, Paul de Vos
Jan 8, 2021·International Journal of Biological Macromolecules·Zhenquan YeChunyan Yan
Mar 8, 2021·International Journal of Biological Macromolecules·Yanfei HeHongxiang Sun
Apr 1, 2021·Lasers in Medical Science·Mariana de Souza CostaMarcelo de Carvalho Filgueiras
Apr 3, 2021·International Journal of Biological Macromolecules·Yang ShiJun-Hui Wang
Jul 5, 2021·Environmental Science and Pollution Research International·Emine YalçınKültiğin Çavuşoğlu
Apr 15, 2020·International Journal of Biological Macromolecules·Priscilla Barbosa Sales AlbuquerqueLuana Cassandra Breitenbach Barroso Coelho
Dec 12, 2021·The Journal of Pharmacy and Pharmacology·Yizhou LvYunpeng Fan

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