Chemical structure of a partially 3-O-methylated mannofucogalactan from edible mushroom Grifola frondosa

Carbohydrate Polymers
Gracy Kelly Faria OliveiraElaine R Carbonero

Abstract

An unusual heteropolysaccharide was isolated from the fruiting bodies of the medicinal mushroom Grifola frondosa, via successive cold aqueous extraction, followed by fractionation through freeze-thawing, precipitation with Fehling solution and dialysis using a membrane with a size exclusion cut-off of 500 kDa. Its chemical structure was determined based on total acid hydrolysis, methylation analysis and NMR studies. The mannofucogalactan had a molar mass of 15.9 × 103 g mol-1, which was determinate by HPSEC-MALLS. This heteropolymer showed to have a main chain of (1 → 6)-linked α-d-Galp partially substituted at O-2 by 3-O-α-d-mannopyranosyl-α-l-fucopyranosyl groups and in a minor proportion with α-l-Fucp single-unit side chains. Moreover, the presence of 3-O-Me-Galp units could also be observed in the main chain of the G. frondosa mannofucogalactan.

Citations

Sep 23, 2018·Carbohydrate Polymers·Renan Akio MotoshimaElaine R Carbonero
Sep 16, 2019·Carbohydrate Polymers·Ruberney S OliveiraElaine R Carbonero
Oct 2, 2021·Journal of Food Biochemistry·Shengfeng YangXiaolin Chen

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