PMID: 22580516May 15, 2012Paper

Chemical structure of phenothiazines and their biological activity

Pharmacological Reports : PR
Agata JaszczyszynBogusława Czarnik-Matusewicz

Abstract

Phenothiazines belong to the oldest, synthetic antipsychotic drugs, which do not have their precursor in the world of natural compounds. Apart from their fundamental neuroleptic action connected with the dopaminergic receptors blockade, phenothiazine derivatives also exert diverse biological activities, which account for their cancer chemopreventive-effect, as: calmodulin- and protein kinase C inhibitory-actions, anti-proliferative effect, inhibition of P-glycoprotein transport function and reversion of multidrug resistance. According to literature data on relations between chemical structure of phenothiazines and their biological effects, the main directions for further chemical modifications have been established. They are provided and discussed in this review paper.

References

Jan 1, 1992·Cancer Chemotherapy and Pharmacology·A Ramu, N Ramu
Jan 1, 1985·Cancer Chemotherapy and Pharmacology·W N HaitE C Cadman
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·A SeeligR M Devant
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·I K PajevaJ K Seydel
Jun 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M Ford
Mar 10, 1998·European Journal of Biochemistry·A Seelig
Aug 28, 1998·European Journal of Pharmacology·J M WilsonH H Van Tol
Sep 11, 1999·Bioorganic & Medicinal Chemistry·T T Sakai, N R Krishna
Mar 30, 2000·International Journal of Clinical Pharmacology and Therapeutics·A SeeligF Wohnsland
Sep 7, 2000·Current Opinion in Oncology·B TanL Ratner
Dec 21, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·A Seelig, E Landwojtowicz
Feb 14, 2002·Molecular Immunology·Gennady Ermak, Kelvin J A Davies
Jun 13, 2002·Il Farmaco·E TeodoriF Gualtieri
Jan 17, 2003·Current Drug Targets·A B Hendrich, K Michalak
Apr 25, 2003·Biochemical and Biophysical Research Communications·Andrzej B HendrichKrystyna Michalak
Sep 26, 2003·Biochimica Et Biophysica Acta·James Y ChenWray H Huestis
Oct 5, 2006·Current Drug Targets·Noboru MotohashiHiroshi Sakagami
Jun 21, 1974·Science·S H SnyderD Greenberg
Nov 4, 2009·The Journal of Physical Chemistry. B·Katarzyna Cieślik-BoczulaAleksander Koll
Jan 19, 2010·Genetics and Molecular Research : GMR·M TaheriR Omranipour
May 29, 2010·Pharmacological Reports : PR·Krystian PlutaMaja Kocieba

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Citations

Nov 12, 2013·European Journal of Pharmacology·Robert E MolokieZaijie J Wang
Apr 1, 2014·Cancer Immunology, Immunotherapy : CII·Jakob TheorellYenan T Bryceson
Sep 1, 2014·Drug Discovery Today·Fabrizio GiordanettoChristian Ottmann
Sep 30, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Beata Morak-MłodawskaDariusz Kuśmierz
Mar 29, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Krzysztof LodarskiBarbara Malawska
Mar 8, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Beata Morak-MłodawskaDariusz Kuśmierz
Jun 24, 2014·Photochemistry and Photobiology·Daniel Limones-HerreroMiguel A Miranda
Dec 3, 2014·European Journal of Medicinal Chemistry·Małgorzata JeleńMaja Kocięba
May 24, 2016·Free Radical Biology & Medicine·Tamara SeredeninaVincent Jaquet
Jun 7, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Joyce C de MelloTiago Rodrigues
Sep 5, 2015·Journal of Biomolecular Structure & Dynamics·Mahboube Eslami MoghadamAli Akbar Saboury
Nov 8, 2016·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Beata Morak-MłodawskaMałgorzata Jeleń
Sep 16, 2016·International Immunopharmacology·Jolanta ArtymKrystian Pluta
Sep 16, 2014·Archiv der Pharmazie·Hadeel T Al-SinjilawiAsaad K M A Ahmad
Jun 20, 2015·Chemical Communications : Chem Comm·S MenichettiC Viglianisi
Feb 10, 2018·Journal of Chromatographic Science·Beata Morak-MlodawskaMalgorzata Jelen
Jul 18, 2017·Organic & Biomolecular Chemistry·Lu ZhangGuanyu Yang
Nov 9, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Petra VaskoHeikki M Tuononen
Dec 1, 2017·Nucleosides, Nucleotides & Nucleic Acids·Mahboube Eslami MoghadamSoheila Sanati
Apr 13, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Andreja LeskovacVesna Vasic
Feb 10, 2019·International Journal of Cancer. Journal International Du Cancer·Vibha SinghArrigo De Benedetti
Jun 20, 2019·FEMS Microbiology Reviews·Elizabeth M Grimsey, Laura J V Piddock
Jul 17, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Beata Morak-MłodawskaMagdalena Jurzak
Jun 30, 2019·Chemistry, an Asian Journal·Seong-Hyun ParkInjae Shin
Jun 7, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Michał OtrębaJared D Warncke
Jan 24, 2020·Luminescence : the Journal of Biological and Chemical Luminescence·Fatimah A M Al-Zahrani
Dec 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Beata Morak-MłodawskaDariusz Kuśmierz
Oct 21, 2017·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Agnieszka SobczakWiesław Malinka
Jan 10, 2014·The Journal of Clinical Investigation·Alejandro GutierrezJon C Aster
Jul 28, 2017·Journal of Neurotrauma·Sylvie LiabeufLaurent Vinay
Mar 21, 2018·Archives of Pharmacal Research·Md Saiful Islam Roney, Song-Kyu Park
Dec 10, 2016·Applied Biochemistry and Biotechnology·Maryam HeydariHossein Farhangian
Feb 27, 2014·The Journal of Antimicrobial Chemotherapy·Sumayah SalieMuazzam Jacobs
Mar 15, 2018·Doklady. Biochemistry and Biophysics·Z I KrutetskayaA D Nozdrachev
Dec 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laura MeloniRudi Beyaert
Jan 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Beata Morak-MłodawskaDariusz Kuśmierz
Sep 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Leon StrzadalaWojciech Kalas

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