PMID: 6159854Aug 1, 1980Paper

Chemical sympathectomy and diurnal fluctuations of noradrenaline calorigenic action in the rat

Archives internationales de physiologie et de biochimie
V M PetrovićV Davidović

Abstract

In the rat, in which a diurnal fluctuation of the sensitivity to noradrenaline was previously found, the effect of injected 6-hydroxydopamine (6-OHDA) was investigated. The heat production and catecholamines contents in the interscapular brown adipose tissue, heart and adrenals were measured. Chemical sympathectomy induces a disappearance of diurnal fluctuation in the sensitivity to injected noradrenaline. In these animals a lower capacity for heat production was found. However, a significant calorigenic effect of injected noradrenaline in 6-OHDA-treated animals was still present. In sympathectomized animals a depletion of noradrenaline from interscapular brown adipose tissue and the heart was observed. Besides, a change in adrenaline/noradrenaline ratio was found in the adrenals.

References

Sep 1, 1976·Acta Physiologica Scandinavica·A Thureson-KleinT Barnard
Jan 1, 1969·Annual Review of Physiology·F Halberg
Feb 1, 1961·Acta Physiologica Scandinavica·U von EULER, F LISHAJKO
Jun 11, 1965·Science·J ASCHOFF

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