Chemical tools for K(+) channel biology.

Biochemistry
Christopher A Ahern, William R Kobertz

Abstract

K(+) channels are revered for their universal action of suppressing electrical activity in nerve and muscle, as well as regulating salt and water transport in epithelial tissues involved in metabolism and digestion. These multisubunit membrane-embedded proteins carry out their physiological chore, selectively allowing the passage of potassium across the membrane, in response to changes in membrane voltage and ligand concentration. Elucidating the diverse gating properties of K(+) channels is of great biological interest since their molecular motions provide insight into how these structurally similar proteins function in a wide variety of tissues. Armed with patch clamps, chart recorders, and now high-resolution structures, electrophysiologists have been dipping into the top tray of the chemist's tool box: synthesizing cysteine-modifying agents and organic cations and grinding up insects, spiders, and other vermin to isolate natural products to poke, probe, and prod K(+) channels. Recently, there has been further cross-fertilization between chemists and K(+) channelologists, resulting in greater accessibility to more elaborate synthetic methodologies and screening approaches. In this review, we catalogue the evolution of chemic...Continue Reading

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J A AndersonR F Gaber
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K L ChoiG Yellen
Dec 1, 1981·Biochimica Et Biophysica Acta·G W Borst-Pauwels
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·P M EnglandD A Dougherty
Jan 10, 1998·The Journal of General Physiology·S Shyng, C G Nichols
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·T W MuirP A Cole
Jul 11, 1998·Molecular Pharmacology·J J SalataM C Sanguinetti
Aug 26, 1998·Methods in Enzymology·R L Nakamura, R F Gaber
Aug 26, 1998·Methods in Enzymology·M Niethammer, M Sheng
Aug 26, 1998·Methods in Enzymology·A Karlin, M H Akabas
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·J P Gallivan, D A Dougherty
Jan 26, 2000·Nature·B C SchroederT J Jentsch
Mar 31, 2000·Nature Structural Biology·R O BlausteinC Miller
Feb 24, 2001·Pflügers Archiv : European journal of physiology·J P Ruppersberg
Aug 5, 1997·Chemical Reviews·Jennifer C. Ma, Dennis A. Dougherty
Apr 27, 2002·Acta Crystallographica. Section D, Biological Crystallography·Sven HovmöllerTomas Ohlson
Jun 1, 2002·Science·Bruce E CohenLily Yeh Jan
Aug 1, 2002·Journal of the American Chemical Society·Francis I ValiyaveetilTom W Muir
Aug 1, 2002·The Journal of General Physiology·Robert O Blaustein
Sep 21, 2002·Trends in Cardiovascular Medicine·G LoussouarnC G Nichols
Mar 13, 2003·Advances in Protein Chemistry·Francisco Bezanilla, Eduardo Perozo
Oct 1, 2003·The Journal of General Physiology·Ramon LatorreOsvaldo Alvarez
May 6, 2004·Angewandte Chemie·Francis I ValiyaveetilRoderick MacKinnon
Oct 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Darren L BeeneSarah C R Lummis
Nov 6, 2004·Neuropharmacology·Zoe A McCrossan, Geoffrey W Abbott
Nov 24, 2004·Nature Neuroscience·Matthew BanghartRichard H Kramer

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Citations

Jan 12, 2013·Analytical and Bioanalytical Chemistry·Kseniya S KudryashovaAlexey V Feofanov
Jul 12, 2013·Nature Reviews. Cancer·Subhashini Sadasivam, James A DeCaprio
May 18, 2011·Bioorganic & Medicinal Chemistry Letters·Zhengmao HuaWilliam R Kobertz
Feb 3, 2015·The Journal of Physiology·Stephan A PlessHarley T Kurata
Dec 19, 2015·PloS One·Wilhelm SalzbergerMarcus Altfeld

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