Chemical tumor ablation with use of a novel multiple-tine infusion system in a canine sarcoma model

Journal of Vascular and Interventional Radiology : JVIR
Andrew Hines-PeraltaS Nahum Goldberg

Abstract

To determine whether larger confluent zones of ablation can be achieved in chemical ablation with use of a multiple-tine infusion device compared with standard needle infusion in a solid tumor model. Multiple canine venereal sarcomas (N=42) were implanted in nine mildly immunosuppressed dogs (treated with 10 mg/kg cyclosporin A twice daily). Tumors incubated for 8-12 weeks grew to a diameter of 5.4 cm+/-1.0. With ultrasound guidance, 8-56 mL of 100% ethanol or 15% acetic acid (diluted in saturated saline solution) were injected in aliquots (2-8 mL) at multiple distances (radius of 0-2 cm) from the needle axis with use of a multiple-tine infusion device. Presence of fluid reflux at the needle puncture site and resultant coagulation diameters were measured within 1 hour and compared with the results of infusion with a standard 18-gauge needle. Multiple-tine infusion enabled greater fluid infusion (15 mL+/-3 to 53 mL+/-3 depending on protocol) than standard needle injection (8 mL+/-1) before reflux was observed at the puncture site (P<.01). Additionally, progressive gains in contiguous tumor coagulation were achieved because acetic acid was infused as far as 2 cm from the needle axis with the multiple-tine device (P<.01; R(2)=0.59...Continue Reading

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Citations

Jan 13, 2009·European Radiology·Rajagopal N AravalliErik N K Cressman
Oct 6, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ming KuangMing-De Lu
May 31, 2014·World Journal of Gastroenterology : WJG·Antonio ColecchiaDavide Festi
Jan 15, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Erik N K Cressman, David A Jahangir
Nov 5, 2008·Journal of Experimental & Clinical Cancer Research : CR·Enrico P SpugniniAlfonso Baldi
Jul 11, 2012·Technology in Cancer Research & Treatment·Rajagopal N AravalliErik N K Cressman
Sep 13, 2012·Experimental and Therapeutic Medicine·Hideto UmeharaKazuichi Okazaki

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