PMID: 490623May 21, 1979Paper

Chemically induced K+ conduction noise in squid axon

The Journal of Membrane Biology
L E MooreD J Poussart

Abstract

Internal perfusion of tetraethylammonium ions (TEA) in squid axons produces a significant high frequency noise component. Although internal TEA suppresses the potassium conductance (GK) noise at relatively low frequencies, it induces high frequency noise which exceeds the intensity of the normal potassium and sodium noise. In addition, the induced noise is dependent on the presence of internal potassium ions (K+) suggesting that this source of noise arises from a modulation of the K+ conductance due to the blocking and unblocking of the K+ channel. The simplest model describing the TEA data is a two-step sequential, pseudo-unimolecular reaction where TEA binds during an open conductance state. A unit channel conductance of 2 pS is estimated from the TEA data as well as noise induced by triethyldecylammonium (TEDA) ions. Thus, these data are consistent with the hypothesis that the channel is blocked whenever the quaternary ammonium ion binding site, located near or within the K+ channel, is occupied.

References

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Dec 4, 1975·The Journal of Membrane Biology·H M FishmanL E Moore
Dec 4, 1975·The Journal of Membrane Biology·H M FishmanD M Poussart
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·H M Fishman
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Sep 1, 1983·Biophysical Journal·H M FishmanL E Moore
Nov 1, 1966·The Journal of General Physiology·C M Armstrong

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Citations

Aug 1, 1980·Pflügers Archiv : European journal of physiology·B NeumckeR Stämpfli
Oct 5, 1979·The Journal of Membrane Biology·H M FishmanL E Moore
Jan 1, 1985·Progress in Biophysics and Molecular Biology·H M Fishman
Jan 1, 1981·The Journal of Membrane Biology·H Gögelein, W Van Driessche
Jan 1, 1981·The Journal of Membrane Biology·H Gögelein, W Van Driessche
Aug 10, 1983·Biochimica Et Biophysica Acta·E FrehlandS Machlup
Apr 30, 1990·Biochimica Et Biophysica Acta·H M FishmanP G Stein

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