Chemically Polymerized Polypyrrole for On-Chip Concentration of Volatile Breath Metabolites

Sensors and Actuators. B, Chemical
Nicholas StrandCristina E Davis

Abstract

A wide range of metabolites are measured in the gas phase of exhaled human breath, and some of these biomarkers are frequently observed to be up- or down-regulated in certain disease states. Portable breath analysis systems have the potential for a wide range of applications in health diagnostics. However, this is currently limited by the lack of concentration mechanisms to enhance trace metabolites found in the breath to levels that can be adequately recorded using miniaturized gas-phase sensors. In this study we have created chip-based polymeric pre-concentration devices capable of absorbing and desorbing breath volatiles for subsequent chemical analysis. These devices appear to concentrate chemicals from both environmental air samples as well as directly from exhaled human breath, and these devices may have applications in lab-on-a-chip-based environmental and health monitoring systems.

References

May 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·R J BlaskiewiczW H Elliott
May 18, 1999·Phytochemistry·V S ParmarC E Olsen
Feb 24, 2001·Journal of Chromatography. a·J Wu, J Pawliszyn
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·S A Kharitonov, P J Barnes
Aug 16, 2003·Analytical Chemistry·Juan M Sanchez, Richard D Sacks
Oct 16, 2003·Journal of Agricultural and Food Chemistry·Deng-Jye YangLucy Sun Hwang
Dec 21, 2004·Organic Letters·Alexander L MandelMichael D Burkart
Sep 2, 2005·The European Respiratory Journal·I HorváthATS/ERS Task Force on Exhaled Breath Condensate
Jun 15, 2006·Analytical Chemistry·Petra S DittrichAndreas Manz
Jun 19, 2008·Analytica Chimica Acta·Shin-Ichi Ohira, Kei Toda
Mar 11, 2009·Environmental Health : a Global Access Science Source·Roel SmoldersGreet Schoeters
Jun 26, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·George PretiAlan Gelperin
Jul 28, 2006·Nanotechnology·Hongliang YanBinglin Zhang

Citations

Sep 27, 2012·Nanoscale Research Letters·Jullieth Suárez-GuevaraPedro Gómez-Romero
Nov 23, 2011·Analytical Chemistry·Miguel del Nogal SánchezBernardo Moreno Cordero
Mar 29, 2012·Nature Communications·Manu S MannoorMichael C McAlpine
Aug 21, 2019·Journal of Breath Research·Mitchell M McCartneyCristina E Davis
Oct 24, 2019·Current Pharmaceutical Design·Anjali Takke, Pravin Shende
May 28, 2010·Analytical Chemistry·Frank L DormanJorge Gardea-Torresdey

Related Concepts

Biological Markers
Down-Regulation
Environment
Medical Devices
Polymers
Polypyrrole
Chemicals
Volatile Substances
Health Information
Metabolite

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