Chemicals in the workplace: incorporating human neurobehavioral testing into the regulatory process

American Journal of Industrial Medicine
R B Dick, H Ahlers

Abstract

In February 1996, the United Kingdom Health and Safety Executive sponsored a workshop on the role of human neurobehavioral tests in the regulation of chemical exposures in the workplace. This paper presents the review of neurobehavioral testing that was initially prepared for the workshop but has been expanded and updated for publication. Information sources for the review were drawn from "preamble to the regulation," in the 1989 air contaminants project, an attempt by the Occupational Safety and Health Administration to update the 1968 regulatory limits of workplace exposures. The scientific citations listed in the preamble provide a chemical database to review for evidence of neurobehavioral testing to support limit setting. Several conclusions emerged: 1) A wide range of nervous system effects were reported in the scientific citations for the 172 chemicals identified with effects on the nervous system; 2) Citations of studies with human neurobehavioral test results are used to support limit setting, but many are old studies primarily of acute effects; 3) There is frequently a delay of several years after publication before studies with neurobehavioral testing are cited in regulatory forums; 4) With the 1989 proposed regulato...Continue Reading

Citations

Jan 7, 2006·International Archives of Occupational and Environmental Health·Christoph van ThrielThomas Brüning
Sep 28, 2006·Chemical Senses·Monique A M SmeetsPamela H Dalton
Jun 10, 2008·Neurotoxicology·Diane S RohlmanChristoph van Thriel
May 1, 2005·Environmental Toxicology and Pharmacology·Andrew M Geller
May 1, 2005·Environmental Toxicology and Pharmacology·Christoph van ThrielAndreas Seeber
Jul 6, 2016·BioMed Research International·Christian MonséThomas Brüning
Sep 21, 2016·Inhalation Toxicology·Gerhard TriebigThomas Bruckner
May 17, 2005·International Archives of Occupational and Environmental Health·Roberto LucchiniLorenzo Alessio
Nov 30, 2005·International Archives of Occupational and Environmental Health·Christoph van ThrielHermann M Bolt
Apr 7, 2006·International Journal of Toxicology·UNKNOWN Cosmetic Ingredient Review Expert Panel
Sep 4, 2014·Archives of Toxicology·Thomas BrüningChristoph van Thriel
Oct 21, 2005·International Archives of Occupational and Environmental Health·Monique A M SmeetsPamela H Dalton
Nov 13, 2020·Neural Plasticity·Stefanie HebaTobias Schmidt-Wilcke
Apr 5, 2003·Toxicology Letters·C van ThrielG A Wiesmüller

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