Chemiexcitation and Its Implications for Disease

Trends in Molecular Medicine
Douglas E BrashExcited-State Medicine Working Group

Abstract

Quantum mechanics rarely extends to molecular medicine. Recently, the pigment melanin was found to be susceptible to chemiexcitation, in which an electron is chemically excited to a high-energy molecular orbital. In invertebrates, chemiexcitation causes bioluminescence; in mammals, a higher-energy process involving melanin transfers energy to DNA without photons, creating the lethal and mutagenic cyclobutane pyrimidine dimer that can cause melanoma. This process is initiated by NO and O2- radicals, the formation of which can be triggered by ultraviolet light or inflammation. Several chronic diseases share two properties: inflammation generates these radicals across the tissue, and the diseased cells lie near melanin. We propose that chemiexcitation may be an upstream event in numerous human diseases.

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Citations

Apr 2, 2020·Nature Reviews. Molecular Cell Biology·Helmut Sies, Dean P Jones
May 28, 2019·Catalysis Science & Technology·Leticia C P GonçalvesMarko D Mihovilovic
Jan 3, 2021·Photochemistry and Photobiology·Ryan M O'Connor, Alexander Greer
Dec 10, 2020·Photochemistry and Photobiology·Luiz D RamosEtelvino J H Bechara
Feb 6, 2019·Chemical Reviews·Paolo Di MascioJean Cadet

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