Chemiluminescence detection of isoniazid using Ru(phen)3(2+)-isoniazid-Ce(IV) system

Journal of Pharmaceutical and Biomedical Analysis
Juan XiZhike He

Abstract

In our experiment, it was observed that isoniazid could enhance the chemiluminescence (CL) emission of tris-(1,10-phenanthroline)ruthenium(II) (Ru(phen)3(2+))-cerium(IV) (Ce(IV)) system and this enhancement effect was dependent on the concentration of isoniazid, based on which, a novel CL system was established for the detection of isoniazid. Under the optimum experimental conditions, the dynamic range and detection limit are 7.0 x 10(-2) to 6.5 microg ml(-1) and 2.5 x 10(-2) microg ml(-1), respectively. The R.S.D. is 3.4% (n = 11). The proposed method has been applied to detect the content of isoniazid in the injection solution with satisfactory results. The possible mechanism of the CL reaction was studied.

Citations

Apr 25, 2006·The Analyst·Bree A GormanNeil W Barnett
Mar 19, 2009·Luminescence : the Journal of Biological and Chemical Luminescence·Huazhen YeGuonan Chen
May 3, 2008·Luminescence : the Journal of Biological and Chemical Luminescence·Li ChenLinpei Jin
Sep 10, 2008·Luminescence : the Journal of Biological and Chemical Luminescence·Fakhr Eldin O SulimanSalama B Salama
Jan 3, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Shifeng LiYonghong Ni
Jun 12, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Muhammad Naeem KhanSang Hak Lee

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