Chemiluminescence determination of gemifloxacin based on diperiodatoargentate (III)-sulphuric acid reaction in a micellar medium

Luminescence : the Journal of Biological and Chemical Luminescence
Fang ZhaoWei Xiong

Abstract

A novel flow-injection chemiluminescence (FI-CL) analysis method for the determination of gemifloxacin in the presence of cetyltrimethylammonium bromide (CTAB) surfactant micelles is described. Strong CL signal was generated during the reaction of gemifloxacin with diperiodatoargentate (III) in a sulfuric acid medium sensitized by CTAB. Under optimum experimental conditions, the CL intensity was linearly related to the concentration of gemifloxacin from 1.0 × 10(-9) to 3.0 × 10(-7) g/mL and the detection limit was 7.3 × 10(-10) g/mL (3σ). The relative standard deviation (RSD) was 1.7 % for a 3.0 × 10(-8) g/mL gemifloxacin solution (11 repeated measurements). The proposed method was successfully applied to the determination of gemifloxacin in pharmaceutical preparations and biological fluids. The possible mechanism of the CL reaction is also discussed briefly.

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Citations

Jul 25, 2015·Biomedical Chromatography : BMC·Clésio Soldateli PaimElfrides Eva Scherman Schapoval
May 18, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Salma Ali Al-TamimiAmal Mohammed Al-Mohaimeed
May 8, 2014·Luminescence : the Journal of Biological and Chemical Luminescence·Nawal A Alarfaj, Maha F El-Tohamy
May 17, 2014·Luminescence : the Journal of Biological and Chemical Luminescence·Guangbin ZhangQiang Fu
Nov 12, 2013·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Mohammad AsgharAbdul Nabi
May 26, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Ahmed KhanMohammed Yaqoob

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