Chemiluminescence-initiated and in situ -enhanced photoisomerization for tissue-depth-independent photo-controlled drug release

Chemical Science
Yufu TangWei Huang

Abstract

Tissue-penetration-depth-independent self-luminescence is highly expected to perform photoisomerization-related bioapplications in vivo to overcome the limitation of shallow tissue-penetration from external photoexcitation. However, it remains extremely challenging because of lacking a target-specific high-intensity self-luminescence to precisely and effectively drive the photoisomerization. Here, we first report a target-specific tissue-depth-independent photoisomerization in vivo by developing a target-specific initiated and in situ-enhanced chemiluminescence (one of self-luminescence) strategy that overcomes the limitation of lacking target-specific high-intensity self-luminescence. Considering that photoisomerization shows boundless glamour in drug-controlled release for disease-specific chemotherapy, we demonstrated applicability of our strategy to apply it in tumor-specific self-luminescence-controlled drug chemotherapy. Specifically, a chemiluminescence substrate and chemiluminescence fluorophore (antitumor drug, CPT) were co-encapsulated in host-guest carriers composed of cyclodextrin and the photoisomerization molecule azobenzene. Tumor-specific H2O2-induced chemiluminescence preliminarily isomerizes azobenzene, trigge...Continue Reading

References

Apr 29, 1998·Nature·I D PodmoreJ Lunec
Dec 8, 2000·FEBS Letters·B HalliwellL H Long
Feb 19, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jichao KangRaymond J Hohl
Jun 27, 2007·Journal of Pharmaceutical Sciences·Tomris Ozben
Aug 19, 2007·Nature Reviews. Molecular Cell Biology·Marco GiorgioPier Giuseppe Pelicci
Aug 21, 2007·Nature Materials·Dongwon LeeNiren Murthy
Nov 9, 2007·International Journal of Cancer. Journal International Du Cancer·Jun FangHiroshi Maeda
Feb 12, 2009·Journal of the American Chemical Society·Richard BosNeil W Barnett
Jun 24, 2009·Colloids and Surfaces. B, Biointerfaces·A L NielsenK L Larsen
Jul 27, 2012·Journal of the American Chemical Society·Huanxiang YuanShu Wang
Apr 26, 2013·Chemical Reviews·Wiktor SzymańskiBen L Feringa
Oct 11, 2013·Chemical Communications : Chem Comm·Huanxiang YuanShu Wang
Oct 25, 2013·Nature Chemistry·Willem A VelemaBen L Feringa
Nov 12, 2013·Angewandte Chemie·Jonas CroissantJeffrey I Zink
Jan 25, 2014·Journal of the American Chemical Society·Willem A VelemaBen L Feringa
Mar 29, 2014·Small·Jonas CroissantJeffrey I Zink
May 27, 2014·Journal of the American Chemical Society·Mercè Izquierdo-SerraPau Gorostiza
Nov 25, 2014·Chemical Communications : Chem Comm·Huanxiang YuanShu Wang
Oct 28, 2016·Journal of the American Chemical Society·Ling HuangGang Han
Feb 14, 2017·Journal of the American Chemical Society·Mahdi KarimiMichael R Hamblin
Aug 31, 2017·Journal of the American Chemical Society·Ori GreenDoron Shabat
Apr 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tao SunChen Jiang

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Citations

Jul 14, 2020·Macromolecular Rapid Communications·Nathan R B Boase
Aug 23, 2019·Chemical Communications : Chem Comm·F ReeßingW Szymanski
Sep 16, 2020·Chemical Society Reviews·Mingwang YangXiaojun Peng
Oct 20, 2020·Photochemistry and Photobiology·Felipe A AugustoWilhelm J Baader
Jan 9, 2021·Inorganic Chemistry·Xuying YuMingyan Wu
Nov 4, 2020·Biomedical Materials·Yan XuBingbo Zhang
Feb 2, 2021·Chemical Society Reviews·Jiong ZhouFeihe Huang
May 7, 2021·Drug Delivery and Translational Research·Endong ZhangShu Wang
Oct 12, 2021·Frontiers in Oncology·Yang LiYiping Wu

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Methods Mentioned

BETA
amidation
irradiate
xenograft

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