PMID: 2483199Jan 1, 1989Paper

[Chemiluminescence of erythrocytes of various age groups in patients with diabetes mellitus].

Laboratornoe delo
L Ia Sukhanova, V V Kamenskaia

Abstract

Hydrogen peroxide-induced chemiluminescence of red cells of various age groups in diabetics was under study. A clinical, laboratory, and instrumental examination of 15 patients with diabetes mellitus was carried out. Red cell fraction chemiluminescence was examined in quantum metric equipment with FEU-39A and FEU-140 radiation detectors sensitive to the visible and UV regions. Intensive fluorescence of the third and, in some cases, of the fourth red cell fractions was observed in the diabetics, in contrast to the reference group of normal subjects (more than 3-fold higher in the patients). A high level of peroxide chemiluminescence observed at the end of examinations of the third and fourth fractions of the diabetics' red cells is an evidence of a high concentration of lipid peroxidation products in the diabetics, increased vs. the norm. Diabetes mellitus involves activation of the red cell fraction free-radical processes, leading to a preterm destruction of functionally active red cells first of all.

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.