Chemistry and Biology of Natural Azoxy Compounds.

Journal of Natural Products
Mario Wibowo, Ling Ding

Abstract

Azoxy compounds belong to a small yet intriguing group of natural products sharing a common functional group with the general structure RN═N+(O-)R. Their intriguing chemical structures, diverse biological activities, and important industrial applications have received attention from researchers in natural product chemistry, total synthesis, and biosynthesis. This review presents current updates about the structural diversity of natural azoxy compounds isolated from different organisms and highlights the enzymes and biological logic involved in their construction. We assume that the identification of key enzymes will provide efficient tools in biocatalysis to generate new azoxy compounds, while genome mining may result in novel natural azoxy compounds of medical and industrial interest.

References

Mar 2, 1977·Journal of the American Chemical Society·R A Moss, M Matsuo
Jan 1, 1975·The Journal of Antibiotics·H UmezawaM Ishizuka
Jun 1, 1992·Trends in Biochemical Sciences·D JahnD Söll
Mar 1, 1991·Infection and Immunity·H M YangP A Sokol
Nov 1, 1989·The Journal of Antibiotics·Y TakahashiG Otani
Jan 1, 1989·The Journal of Antibiotics·N ImamuraS Omura
Jun 1, 1986·The Journal of Antibiotics·R CalvinoL Gabriel
Feb 1, 1986·The Journal of Antibiotics·M YamatoM Hori
Mar 25, 1970·Journal of the American Chemical Society·W J McGahren, M P Kunstmann
Feb 22, 1969·Nature·R Schoental
May 7, 1969·Journal of the American Chemical Society·W J McGahren, M P Kunstmann
Aug 1, 1994·The Journal of Antibiotics·Y AokiM Arisawa
Jan 1, 1996·Antimicrobial Agents and Chemotherapy·Y AokiM Arisawa
Jul 17, 2003·Planta medica·Giulia BianchiSergio Quaroni
Sep 26, 2006·Bioorganic & Medicinal Chemistry·Yuuko KariyaJun'ichi Kobayashi
May 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ram P GargRonald J Parry
Sep 28, 2012·Journal of Natural Products·Ling DingChristian Hertweck
Oct 17, 2012·Journal of Natural Products·Ken W L YongMary J Garson
Nov 15, 2012·The Journal of Antibiotics·Niko ManderscheidRoderich D Süssmuth
Apr 13, 2013·Journal of Natural Products·Lachlan M Blair, Jonathan Sperry
Apr 1, 1989·Journal of Chemical Ecology·M D Bowers, Z Larin
Dec 18, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Glen E KisbyPeter S Spencer
Aug 25, 2015·Chembiochem : a European Journal of Chemical Biology·Hirofumi KunitakeKenji Arakawa
Apr 5, 2017·Chemical Reviews·Abraham J WaldmanEmily P Balskus
Jul 13, 2018·Journal of the American Chemical Society·Kenichi MatsudaMakoto Nishiyama
Jun 22, 2019·European Journal of Medicinal Chemistry·Mariko WatanabeRyouichi Horie
Oct 9, 2019·Nature Communications·Yuan-Yang GuoYong-Quan Li
Jun 4, 2020·Current Opinion in Chemical Biology·Yohei Katsuyama, Kenichi Matsuda

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Citations

Oct 2, 2021·ChemMedChem·Michał G NowakMaria J Milewska

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