Chemistry and biology of reactive species with special reference to the antioxidative defence status in pancreatic β-cells

Biochimica Et Biophysica Acta. General Subjects
Sigurd Lenzen

Abstract

Diabetes mellitus is a serious metabolic disease. Dysfunction and subsequent loss of the β-cells in the islets of Langerhans through apoptosis ultimately cause a life-threatening insulin deficiency. The underlying reason for the particular vulnerability of the β-cells is an extraordinary sensitivity to the toxicity of reactive oxygen and nitrogen species (ROS and RNS) due to its low antioxidative defense status. This review considers the different aspects of the chemistry and biology of the biologically most important reactive species and their chemico-biological interactions in the β-cell toxicity of proinflammatory cytokines in type 1 diabetes and of lipotoxicity in type 2 diabetes development. The weak antioxidative defense equipment in the different subcellular organelles makes the β-cells particularly vulnerable and prone to mitochondrial, peroxisomal and ER stress. Looking upon the enzyme deficiencies which are responsible for the low antioxidative defense status of the pancreatic β-cells it is the lack of enzymatic capacity for H2O2 inactivation at all major subcellular sites. Diabetes is the most prevalent metabolic disorder with a steadily increasing incidence of both type 1 and type 2 diabetes worldwide. The weak prot...Continue Reading

Citations

May 15, 2018·Antioxidants & Redox Signaling·Jean-Philippe DeglasseJean-Christophe Jonas
Dec 20, 2018·Journal of Cellular Physiology·Mohammad Javad Saeedi BorujeniAmid Yazdani
Nov 20, 2018·Antioxidants & Redox Signaling·Petr JežekLydie Plecitá-Hlavatá
Jan 20, 2019·The Journal of Biological Chemistry·Jennifer S StancillJohn A Corbett
Apr 3, 2019·Annals of the New York Academy of Sciences·Yumi ImaiJoseph A Promes
May 2, 2019·Molecular Reproduction and Development·Amira Abdalla Abdelshafy MohamedYaping Jin
Nov 7, 2019·Journal of Physiology and Biochemistry·Tomasz Szkudelski, Katarzyna Szkudelska
Jan 12, 2019·Cell Death & Disease·Karolina TykaEwa Gurgul-Convey
Apr 16, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer S StancillJohn A Corbett
Jul 22, 2018·Journal of Molecular Endocrinology·Jakob Bondo HansenThomas Mandrup-Poulsen
Aug 2, 2019·Molecular Biology Reports·Safa AydınFikrettin Şahin
Dec 10, 2019·Oxidative Medicine and Cellular Longevity·María L RodríguezÁngel Luis Ortega
Jun 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Petr JežekLydie Plecitá-Hlavatá
Jun 30, 2019·Oxidative Medicine and Cellular Longevity·Lydie Plecitá-HlavatáPetr Ježek
Nov 7, 2019·International Journal of Molecular Sciences·Mirza Muhammad Fahd QadirRicardo Luis Pastori
Dec 22, 2019·International Journal of Molecular Sciences·Giuseppina Emanuela GriecoGuido Sebastiani
Oct 6, 2020·The American Journal of Chinese Medicine·Tian-Qi BaoPing Li
Nov 2, 2019·Biochimica Et Biophysica Acta. Biomembranes·Anna LaporteMatthias Elsner
Oct 22, 2019·Journal of Molecular Biology·Leticia P Roma, Jean-Christophe Jonas
Nov 30, 2020·Free Radical Biology & Medicine·Eloisa Aparecida Vilas-BoasLeticia Prates Roma
Feb 13, 2021·Antioxidants·Petr JežekLydie Plecitá-Hlavatá
Feb 19, 2021·Cellular Signalling·J Duque EscobarElke Oetjen
Mar 12, 2021·The Journal of Nutrition·Sae-In S KayAdrien A Eshraghi
May 31, 2020·Redox Biology·Eva-Maria HanschmannThomas Linn
Apr 4, 2021·Antioxidants·Štěpánka BenákováLydie Plecitá-Hlavatá
Apr 24, 2021·Redox Biology·Christina KrügerMatthias Elsner
Jun 29, 2021·Antioxidants & Redox Signaling·Petr JežekLydie Plecitá-Hlavatá
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Jia-Yue DuanLing-Qing Yuan
Aug 8, 2021·Free Radical Biology & Medicine·Christina KrügerSigurd Lenzen
Nov 10, 2021·Free Radical Biology & Medicine·Markus Waldeck-WeiermairThomas Michel

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