Chemistry and biology of the caged Garcinia xanthones.

Chemistry : a European Journal
Oraphin ChantarasriwongEmmanuel A Theodorakis

Abstract

Natural products have been a great source of many small molecule drugs for various diseases. In spite of recent advances in biochemical engineering and fermentation technologies that allow us to explore microorganisms and the marine environment as alternative sources of drugs, more than 70 % of the current small molecule therapeutics derive their structures from plants used in traditional medicine. Natural-product-based drug discovery relies heavily on advances made in the sciences of biology and chemistry. Whereas biology aims to investigate the mode of action of a natural product, chemistry aims to overcome challenges related to its supply, bioactivity, and target selectivity. This review summarizes the explorations of the caged Garcinia xanthones, a family of plant metabolites that possess a unique chemical structure, potent bioactivities, and a promising pharmacology for drug design and development.

References

Feb 1, 1996·Phytochemistry·J AsanoT Yoshii
Mar 11, 1998·Natural Product Reports·P M Dewick
Aug 28, 1998·Science·N A Thornberry, Y Lazebnik
Apr 14, 1999·Cell Death and Differentiation·A G Porter, R U Jänicke
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Mar 31, 2000·Pharmacology & Therapeutics·A K LarsenA Skladanowski
Apr 29, 2000·Journal of Natural Products·O ThoisonT Sévenet
May 10, 2000·Nature Medicine·G Kroemer, J C Reed
Jun 29, 2000·Annual Review of Biochemistry·W C EarnshawS H Kaufmann
Aug 15, 2002·Chemical Reviews·Ulf M Lindström
Sep 5, 2002·Nature Reviews. Cancer·Suzanne Cory, Jerry M Adams
Feb 1, 2003·Cancer Cell·John C Reed
Mar 15, 2003·Natural Product Reports·Andrew R Knaggs
Apr 26, 2003·Organic Letters·Eric J TisdaleEmmanuel A Theodorakis
Jul 26, 2003·Journal of Natural Products·Vatcharin RukachaisirikulWalter C Taylor
May 15, 1961·Experientia·K V NAGESWARA RAO, P L NARASIMHA RAO
Sep 23, 2003·Angewandte Chemie·K C NicolaouAndreas Ritzén
Jan 16, 2004·Bioorganic & Medicinal Chemistry·Han-Zhong ZhangSui Xiong Cai
Jan 20, 2004·Organic & Biomolecular Chemistry·Eric J TisdaleEmmanuel A Theodorakis
Mar 12, 2004·Annual Review of Plant Physiology and Plant Molecular Biology·Klaus M. Herrmann, Lisa M. Weaver
Jun 5, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E RyschichJ Schmidt
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Eric J TisdaleEmmanuel A Theodorakis
Aug 18, 2004·The International Journal of Biochemistry & Cell Biology·Philip Aisen
Feb 25, 2005·Planta medica·Vatcharin RukachaisirikulWalter C Taylor
Mar 31, 2005·Blood·John C Reed, Maurizio Pellecchia
Jun 22, 2005·World Journal of Gastroenterology : WJG·Wei LiuSheng-Tao Yuan
Jul 6, 2005·Chemical & Pharmaceutical Bulletin·Yaowapa SukpondmaSouwalak Phongpaichit
Jul 26, 2005·Journal of Natural Products·Yaowapa SukpondmaSouwalak Phongpaichit
Aug 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shailaja KasibhatlaBen Tseng
Oct 28, 2005·Current Medicinal Chemistry·M E Sousa, M M M Pinto
Nov 29, 2005·Phytochemistry·W MahabusarakamW C Taylor
Dec 6, 2005·Biological & Pharmaceutical Bulletin·Quan-Bin HanHong-Xi Xu
Feb 8, 2006·Chemical & Pharmaceutical Bulletin·Quan-Bin HanHong-Xi Xu
Apr 29, 2006·Cell Death and Differentiation·D ZhaiJ C Reed
Aug 22, 2006·Basic & Clinical Pharmacology & Toxicology·Qinglong GuoZhaoqiu Wu
Aug 23, 2006·Acta Pharmacologica Sinica·Yi-tong LiuGuang-ji Wang

❮ Previous
Next ❯

Citations

Mar 29, 2013·Journal of Natural Medicines·Reika MoriHiroshi Morita
Mar 7, 2012·Journal of the American Chemical Society·Jing XuEmmanuel A Theodorakis
May 3, 2011·Journal of Asian Natural Products Research·Yong-En GuoTong-Cun Zhang
Sep 18, 2012·Fitoterapia·Yun-Xia DengZhi-Yu Shao
Dec 15, 2015·Archives of Pharmacal Research·Da-Hong LiZhan-Lin Li
Dec 10, 2015·Journal of Natural Medicines·Yating SunHuiming Hua
Jul 30, 2015·Journal of Natural Products·Kevin CottetMartine Largeron
Dec 27, 2011·Pharmaceutical Biology·Natthinee AnantachokeVichai Reutrakul
Jan 8, 2014·Journal of Asian Natural Products Research·Hong-Min WangWei-Min Zhao
Jul 29, 2016·Proceedings of the National Academy of Sciences of the United States of America·Kendrick H YimLeonard Neckers
May 26, 2017·Organic & Biomolecular Chemistry·Sheng-Li NiuZhan-Lin Li
Sep 17, 2014·Natural Product Reports·Tim WezemanKye-Simeon Masters
Apr 26, 2012·Chembiochem : a European Journal of Chemical Biology·Gianni GuizzuntiEmmanuel A Theodorakis
Nov 2, 2016·Antimicrobial Agents and Chemotherapy·Hangjun KeAkhil B Vaidya
Jun 2, 2016·Antimicrobial Agents and Chemotherapy·Yanmei HuJames M Bullard
Jul 1, 2018·Basic & Clinical Pharmacology & Toxicology·Lili LiangWeihui Zeng
Mar 13, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guo-Ying ZuoZhong-Qi Bian
Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·João RibeiroMadalena M M Pinto
Apr 21, 2011·Angewandte Chemie·Stéphane P Roche, John A Porco
Dec 20, 2013·Angewandte Chemie·Jing XuEmmanuel A Theodorakis
Nov 27, 2016·Oncotarget·Karin HientzThomas Efferth
Mar 15, 2012·Chemistry, an Asian Journal·Jing XuEmmanuel A Theodorakis
Mar 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Fang BaiRachel Nechushtai
Apr 9, 2013·Organic & Biomolecular Chemistry·Kristyna M ElbelEmmanuel A Theodorakis
Mar 13, 2012·Organic & Biomolecular Chemistry·Xiaojin ZhangQidong You
Feb 4, 2021·Journal of Biochemical and Molecular Toxicology·Zhixin ZhangGang Cao
Oct 13, 2020·Pharmacology & Therapeutics·Laura MasuelliRoberto Bei
Dec 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hosakatte Niranjana MurthyAbdullah Ibrahim
May 13, 2021·European Journal of Pharmacology·Abdullah Al MamunJian Xiao
Jun 3, 2021·Cells·Deepu PanditaHosam O Elansary

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Chemical & Pharmaceutical Bulletin
Yaowapa SukpondmaSouwalak Phongpaichit
Current Medicinal Chemistry
Quan Bin Han, Hong-Xi Xu
Organic & Biomolecular Chemistry
Ayse BatovaEmmanuel A Theodorakis
Organic & Biomolecular Chemistry
Oraphin ChantarasriwongEmmanuel A Theodorakis
© 2021 Meta ULC. All rights reserved