Chemistry of mixed-ligand oxidovanadium(IV) complexes of aroylhydrazones incorporating quinoline derivatives: Study of solution behavior, theoretical evaluation and protein/DNA interaction

Journal of Inorganic Biochemistry
Atanu BanerjeeRupam Dinda

Abstract

A series of eight hexacoordinated mixed-ligand oxidovanadium(IV) complexes [VO(Lx)(LN-N)] (1-8), where Lx = L1 - L4 are four differently substituted ONO donor aroylhydrazone ligands and LN-N are N,N-donor bases like 2,2'-bipyridine (bipy) (1, 3, 5 and 7) and 1,10-phenanthroline (phen) (2, 4, 6 and 8), have been reported. All synthesized complexes have been characterized by various physicochemical techniques and molecular structures of 1 and 6 were determined by X-ray crystallography. With a view to evaluate the biological activity of the VIVO species, the behavior of the systems VIVO2+/Lx, VIVO2+/Lx/bipy and VIVO2+/Lx/phen was studied as a function of pH in a mixture of H2O/DMSO 50/50 (v/v). DFT calculations allowed finding out the relative stability of the tautomeric forms of the ligands, and predicting the structure of vanadium complexes and their EPR parameters. To study their interaction with proteins, firstly the ternary systems VIVO2+/L1,2 with 1-methylimidazole, which is a good model for histidine binding, were examined. Subsequently the interaction of the complexes with lysozyme (Lyz), cytochrome c (Cyt) and bovine serum albumin (BSA) was studied. The results indicate that the complexes showed moderate binding affinity ...Continue Reading

References

Apr 17, 1992·Journal of Medicinal Chemistry·J H McNeillC Orvig
May 1, 1980·Basic Research in Cardiology·H U Meisch, H J Bielig
Sep 25, 1995·Biochemical and Biophysical Research Communications·H SakuraiH Tamura
Jul 8, 2000·Journal of Inorganic Biochemistry·D Rehder
Apr 11, 2001·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·M RangelH Sakurai
Dec 26, 2001·Chemical Reviews·K H ThompsonC Orvig
Mar 20, 2002·Current Topics in Medicinal Chemistry·A Avdeef
Apr 10, 2002·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Dieter RehderDongren Wang
Dec 3, 2002·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Katherine H ThompsonChris Orvig
Jan 11, 2003·Natural Product Reports·Joseph P Michael
Feb 28, 2004·European Journal of Medicinal Chemistry·Luisa SaviniM Barbara Pisano
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Timothy B ChastonDes R Richardson
Jan 18, 2006·Methods in Enzymology·Kerstin Strupat
Dec 25, 2007·Acta Crystallographica. Section A, Foundations of Crystallography·George M Sheldrick
Feb 6, 2008·Natural Product Reports·Joseph P Michael
Oct 25, 2008·Chemical Society Reviews·Hiromu SakuraiHiroyuki Yasui
Mar 18, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Tamás JakuschTamás Kiss
Jan 22, 2010·Mini Reviews in Medicinal Chemistry·Suresh KumarHimanshu Gupta
Feb 6, 2010·European Journal of Medicinal Chemistry·Madalina Veronica AngelusiuGabriela Laura Almajan
Mar 27, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Daniele SannaEugenio Garribba
Sep 18, 2010·Current Medicinal Chemistry·J Costa Pessoa, I Tomaz
Sep 30, 2010·Inorganic Chemistry·Yi SunBao-Wen Zhang
Mar 26, 2011·Inorganic Chemistry·Daniele SannaEugenio Garribba
Apr 1, 2010·Journal of Pharmacy & Bioallied Sciences·Sandhya BawaRajiv Kumar

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