Chemistry of mutagens and carcinogens in broiled food

Environmental Health Perspectives
S Nishimura

Abstract

From a chemical point of view, the following subjects are important areas in studies on mutagens and carcinogens in broiled foods. In addition to heterocyclic amines which need microsomal activation, the structural elucidation of more labile direct-acting mutagens is necessary. It is known that there are still various unknown minor mutagens in broiled foods. Although the structural characterization of such compounds is more difficult, it is important since they might be hazardous in spite of their low mutagenicity. A more feasible and easier method for quantitative analysis of mutagens, in addition to HPLC and GC/MS methods presently employed, must be developed. The mechanism of formation of mutagens by broiling of food should be studied. An effective chemical method to prevent formation of mutagens or to destroy them, once formed, should be developed.

Citations

Aug 1, 1986·Environmental Health Perspectives·C G EdmondsJ A McCloskey
Jun 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J TureskyH Milon
Nov 1, 1988·Mutation Research·G M AlinkJ S Felton
Jan 1, 1988·Nutrition and Cancer·V E Archer
Dec 5, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·P Pais, M G Knize

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