Chemistry of phospholipid oxidation

Biochimica Et Biophysica Acta
Ana Reis, Corinne M Spickett

Abstract

The oxidation of lipids has long been a topic of interest in biological and food sciences, and the fundamental principles of non-enzymatic free radical attack on phospholipids are well established, although questions about detail of the mechanisms remain. The number of end products that are formed following the initiation of phospholipid peroxidation is large, and is continually growing as new structures of oxidized phospholipids are elucidated. Common products are phospholipids with esterified isoprostane-like structures and chain-shortened products containing hydroxy, carbonyl or carboxylic acid groups; the carbonyl-containing compounds are reactive and readily form adducts with proteins and other biomolecules. Phospholipids can also be attacked by reactive nitrogen and chlorine species, further expanding the range of products to nitrated and chlorinated phospholipids. Key to understanding the mechanisms of oxidation is the development of advanced and sensitive technologies that enable structural elucidation. Tandem mass spectrometry has proved invaluable in this respect and is generally the method of choice for structural work. A number of studies have investigated whether individual oxidized phospholipid products occur in v...Continue Reading

References

Sep 16, 1991·Biochemical and Biophysical Research Communications·P PolleselloN E Saris
May 1, 1988·Journal of Biochemistry·T MiyazawaT Kaneda
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·X Han, R W Gross
Nov 21, 1996·Biochemical and Biophysical Research Communications·H AraiJ Terao
Apr 8, 2000·Free Radical Biology & Medicine·A JerlichC M Spickett
Jun 30, 2000·Biochemical and Biophysical Research Communications·Q T LiB K Tan
Aug 5, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J M Pearce, R A Komoroski
Aug 18, 2000·Free Radical Biology & Medicine·G SubbanagounderJ A Berliner
Oct 14, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·G SubbanagounderJ A Berliner
Dec 8, 2000·FEBS Letters·B HalliwellL H Long
Oct 26, 2001·Free Radical Biology & Medicine·J ArnholdJ Schiller
Dec 26, 2001·Current Opinion in Hematology·J David Lambeth
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Mar 23, 2002·Free Radical Biology & Medicine·Mario ComportiLucia Ciccoli
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Henry F HoffRobert L Salomon
Mar 5, 2003·Free Radical Biology & Medicine·Oleg M PanasenkoJürgen Arnhold
Jul 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Paul R S BakerBruce A Freeman
Aug 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·B Kalyanaraman
Jan 25, 2005·Journal of Vascular Research·Matthias S GöpfertAlois Sellmayer
Feb 4, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mark J AlbersStefan Blüml
Mar 9, 2005·Chemistry and Physics of Lipids·Robert G Salomon
Aug 24, 2005·The Journal of Biological Chemistry·Gopal K MaratheJeffrey B Travers
Aug 30, 2005·Archives of Biochemistry and Biophysics·Revathy Senthilmohan, Anthony J Kettle
Aug 30, 2005·Biochemical and Biophysical Research Communications·Etsuo NikiNoriko Noguchi
Sep 15, 2005·Chemical Reviews·Waldemar AdamValeri P Kazakov

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Citations

Mar 21, 2013·Current Atherosclerosis Reports·Maceler Aldrovandi, Valerie B O'Donnell
Jun 19, 2013·Journal of Proteomics·Rosário M DominguesCorinne M Spickett
Jan 23, 2013·Chemistry Central Journal·Xiao-Jing ZhangJian-Bo Wan
Jul 27, 2014·Biochimie·Aurélien L FurlanJulie Géan
May 7, 2015·Journal of Liposome Research·Andrii K MelnykAndriy I Vovk
Jun 6, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Arindam MaityKira Astakhova
Dec 26, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Kristina A RunasNoah Malmstadt
Jun 15, 2015·Redox Biology·Giancarlo AldiniDolores Pérez-Sala
Mar 8, 2016·Molecular Aspects of Medicine·Christina MauerhoferValery N Bochkov
Mar 8, 2016·Biochimica Et Biophysica Acta·Martin LidmanGerhard Gröbner
Nov 10, 2015·Biochimica Et Biophysica Acta·Andrés H ThomasMariana Vignoni
Jul 8, 2014·Biochimica Et Biophysica Acta·Shalene SankhagowitNoah Malmstadt
May 28, 2014·The Journal of Membrane Biology·Elżbieta Rudolphi-SkórskaMaria Zembala
Mar 5, 2014·Rapid Communications in Mass Spectrometry : RCM·Eliana AlvesM Rosário M Domingues
Oct 31, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Jacqueline J KnoblochDuncan J McGillivray
Apr 10, 2013·Biochimica Et Biophysica Acta·Clare L Hawkins, Michael J Davies
Jul 8, 2014·Oxidative Medicine and Cellular Longevity·Antonio AyalaSandro Argüelles
Feb 24, 2015·Analytical and Bioanalytical Chemistry·Zhixu NiMaria Fedorova
Feb 20, 2015·Antioxidants & Redox Signaling·Corinne M Spickett, Andrew R Pitt
May 16, 2015·Oxidative Medicine and Cellular Longevity·Christian Solís-CaleroFrancisco Muñoz
Mar 10, 2015·Critical Reviews in Food Science and Nutrition·Francisco J Hidalgo, Rosario Zamora
Jun 5, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Tiago Mendes FerreiraO H Samuli Ollila
Sep 21, 2016·Pharmaceutics·Carla B RocesYvonne Perrie
Nov 1, 2016·Journal of the American Society for Mass Spectrometry·Daniela CoutoPedro Domingues
Sep 14, 2016·The Journal of Membrane Biology·Carlos de la HabaJosé R Palacio
Mar 16, 2017·Metabolites·Nadine S TaylorMark R Viant
Mar 30, 2017·ACS Chemical Biology·Ting-Yi WangJean-Philippe Pellois
Apr 17, 2017·Redox Biology·Agnieszka GęgotekElżbieta Skrzydlewska
May 31, 2017·Current Eye Research·Burkhardt S Schuett, Thomas J Millar
Mar 8, 2017·Scientific Reports·Vincent BessonneauJanusz Pawliszyn
Jul 23, 2013·Journal of Lipid Research·Alfred N FontehMichael G Harrington
Feb 17, 2018·Bioanalysis·Jeremy P KoelmelJohn A Bowden
Jun 30, 2015·Physical Chemistry Chemical Physics : PCCP·Estibalitz FernándezOlga López
Sep 7, 2017·Journal of Lipid Research·Ryohei AoyagiMakoto Arita

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