PMID: 15374467Nov 1, 1990Paper

Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review

Archives of Gerontology and Geriatrics
I Zs -Nagy

Abstract

The name idebenone (CV-2619) was given to a synthetic compound the chemical structure of which is 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (commercial name in Japan: Avan). Although it is insoluble in water, suspensions of it can be applied and are absorbed relatively well from the intestine. Its acute toxicity is very low, and is well tolerated also in subacute and chronic treatments. It displayed no immunogenic or mutagenic side effects in the models studied so far. Pharmacological studies of idebenone revealed that (i) it acts as a free radical scavenger and protects the mitochondrial membrane against lipid peroxidation; (ii) it prevents platelet aggregation; (iii) it improves vascular disorders due to strokes or experimental cerebral ischemia; (iv) it recovers the cholinergic and monoaminergic changes in the ischemic brain; (v) it improves overall brain function (including memory, also) in various animal models. Pharmacokinetic studies have confirmed that it reaches the brain cells even after per os administration. The main conclusion from the experimental data was that idebenone may be of beneficial effect for the neurological disorders related to cerebral ischemia even in humans: the results obtained so...Continue Reading

References

May 1, 1989·Archives of Gerontology and Geriatrics·Y NagaiY Nagawa
May 1, 1989·Archives of Gerontology and Geriatrics·M SunoA Nagaoka
May 1, 1989·Archives of Gerontology and Geriatrics·M Suno, A Nagaoka
Mar 1, 1989·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Y KiyotaA Nagaoka
May 1, 1989·Archives of Gerontology and Geriatrics·Y KiyotaA Nagaoka
May 1, 1989·Archives of Gerontology and Geriatrics·Y NagaiA Nagaoka
May 1, 1989·Archives of Gerontology and Geriatrics·M Suno, A Nagaoka
May 1, 1989·Archives of Gerontology and Geriatrics·T NakanoY Kifune
May 1, 1988·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·M Suno, A Nagaoka
Jun 1, 1987·Pharmacology, Biochemistry, and Behavior·M Miyamoto, A Nagaoka
Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·Y KiyotaY Nagawa
Aug 1, 1986·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Y NagaiA Nagaoka
Dec 28, 1984·Biochemical and Biophysical Research Communications·M Suno, A Nagaoka
Nov 1, 1984·Japanese Journal of Pharmacology·N YamazakiY Nagawa
Jun 1, 1984·Japanese Journal of Pharmacology·M Suno, A Nagaoka

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Citations

Jan 7, 2009·European Journal of Clinical Pharmacology·Michael BodmerJürgen Drewe
Nov 1, 1990·Archives of Gerontology and Geriatrics·I SemseiI Zs -Nagy
Nov 1, 1990·Archives of Gerontology and Geriatrics·I Zs -Nagy, R A Floyd
Nov 1, 1990·Archives of Gerontology and Geriatrics·K NagyI Zs -Nagy
Nov 1, 1990·Archives of Gerontology and Geriatrics·G Lustyik, J J O'Leary
Nov 1, 1992·Archives of Gerontology and Geriatrics·J BoniS Gherardi
Nov 1, 1992·Archives of Gerontology and Geriatrics·M LingettiF Di Grazia
Nov 1, 1992·Archives of Gerontology and Geriatrics·U SeninM Fioravanti
Nov 1, 1992·Archives of Gerontology and Geriatrics·G NappiM Fioravanti
Jan 1, 1997·Archives of Gerontology and Geriatrics·L BetaC Mariani
Oct 3, 2002·Molecular Genetics and Metabolism·Vanna GeromelPierre Rustin
Jun 18, 2002·Trends in Molecular Medicine·Agnès RötigPierre Rustin
Dec 26, 1992·Annals of the New York Academy of Sciences·I Zs-Nagy
Mar 3, 2009·Journal of Cosmetic Dermatology·Michael F WempePeter J Rice
Nov 23, 2005·Biochemical and Biophysical Research Communications·Hana RauchováZdenek Drahota
Aug 20, 2008·Expert Opinion on Pharmacotherapy·Caterina Tonon, Raffaele Lodi
May 10, 2015·Expert Opinion on Therapeutic Patents·Anna Maria Papini, Enrico König
Dec 30, 2014·International Journal of Pharmaceutics·Abhay Y KyadarkunteVarsha B Pokharkar
Jun 18, 2016·Oxidative Medicine and Cellular Longevity·Alexey V LokhmatikovArmen Y Mulkidjanian
Nov 26, 2015·Journal of Analytical Methods in Chemistry·Sonoube KombathJoël Schlatter
Sep 2, 2016·Pharmaceutical Development and Technology·Joël SchlatterJean-Eudes Fontan
Aug 14, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S MatsumotoS Ishida
Dec 30, 2008·Pharmacological Reviews·Christopher S Wilcox, Adam Pearlman
May 26, 2006·Antimicrobial Agents and Chemotherapy·Sakiko InatsuKumiko Nagata
Feb 3, 2018·Molecular Medicine Reports·Jiahui ZhangHuabiao Chen
Oct 27, 2004·Journal of Inherited Metabolic Disease·C MühlhausenK Ullrich

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