ChemMatrix, a poly(ethylene glycol)-based support for the solid-phase synthesis of complex peptides

Journal of Combinatorial Chemistry
Fayna García-MartinFernando Albericio

Abstract

CM (ChemMatrix) resin is a new, totally poly(ethylene glycol) (PEG)-based resin, made exclusively from primary ether bonds and, therefore, highly chemically stable. It exhibits good loading and is user-friendly because of its free-flowing form upon drying. It performs excellently for the preparation of hydrophobic, highly structured, and poly-Arg peptides, as compared to polystyrene (PS) resins. In the most striking example, stepwise solid-phase assembly of the highly complex beta-amyloid (1-42) peptide resulted in a crude material of 91% purity. In contrast, literature procedures using PS or PEG-PS-based resins for this peptide required convergent approaches, additional time-consuming steps, or both. In addition to the difficulties of its synthesis, characterization of the beta-amyloid (1-42) peptide as a monomer is also a challenge, and methods for characterization by HPLC and MALDI-TOF have also been developed.

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Citations

May 1, 2009·Future Medicinal Chemistry·Aikaterini A ZompraFernando Albericio
Oct 21, 2014·ACS Combinatorial Science·Prabhakar CherkupallyFernando Albericio
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