Chemo-pharmaceutical studies on the glycosphingolipid constituents from echinoderm, sea cucumbers, as the medicinal materials

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Koji Yamada


Glycosphingolipids (GSLs), together with glycopeptides, are typical constitutents of various cell membranes in a wide variety of organisms. In particular, it is known that GSLs have numerous physiological functions due to variations in the sugar chain, in spite of the very small quantity of constituents. Those are classified into cerebrosides, sulfatides, ceramide oligohexosides, globosides, and gangliosides based on the constituent sugars. Gangliosides, sialic acid-containing GSLs, are especially enriched in the brain and nervous tissues and are involved in the regulation of many cellular events. Recently, a number of GSLs have been isolated from marine invertebrates such as echinoderms, poriferans, and mollusks. We have also been researching biologically active GSLs from echinoderms to elucidate the structure-function relationships of GSLs and to develop novel medicinal resources. This review summarizes the structures and biological activities of GSLs from sea cucumbers. This study showed that the characteristics of GSLs and structure-activity relationships had neuritogenic activity toward the rat pheochromocytoma cell line PC12. That is, most of the cerebroside constituents of the sea cucumber are same glucocerebrosides as i...Continue Reading


Jan 1, 1976·Advances in Experimental Medicine and Biology·B CeccarelliM Finesso
Jan 1, 1979·Journal of Supramolecular Structure·J I Morgan, W Seifert
Aug 1, 1990·Journal of Biochemistry·H KuboM Hoshi
Mar 1, 1969·Brain Research·K V Anderson, D Symmes
Feb 1, 1982·Muscle & Nerve·F NoridoA Gorio
Oct 30, 1981·Science·F J RoisenG Yorke
Jan 1, 1995·Dermatology : International Journal for Clinical and Investigative Dermatology·Y HamamotoC Asagami
Jun 1, 1996·Chemical & Pharmaceutical Bulletin·R TanakaN Noda
Mar 1, 1996·Biological & Pharmaceutical Bulletin·E KobayashiY Koezuka
Mar 21, 1998·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·T NatoriT Higa
Dec 1, 1995·Physical Review. B, Condensed Matter·R M Carter van der Walt DM
Jun 28, 2000·Journal of Natural Products·A LoukaciM Guyot
Apr 5, 2001·Biochimica Et Biophysica Acta·M SaitoK Sugiyama


Aug 9, 2011·Bioscience, Biotechnology, and Biochemistry·Jie XuChang-Hu Xue
Dec 8, 2006·Bioscience, Biotechnology, and Biochemistry·Tatsuya SugawaraTakashi Hirata
Mar 17, 2004·The Journal of Toxicological Sciences·Mitsuyoshi MotoKunitoshi Mitsumori
Aug 15, 2015·PloS One·Yoshifumi NishikawaMasao Ohnishi
Jul 11, 2018·Marine Drugs·Ariana A Vasconcelos, Vitor H Pomin

Related Concepts

Sea Cucumbers
Structure-Activity Relationship
Drug Modeling
PC12 Cells
Rats, Laboratory

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