Chemo-prevention in superficial bladder cancer using mitomycin C: a survey of the practice patterns of British urologists

BJU International
Nicholas S ClarkeRajiv Puri

Abstract

To assess the use of mitomycin C, by urologists within the UK, as a single-dose intravesical agent. Current European recommendations are to use one dose after any new tumour resection. We assessed the current patterns of mitomycin C usage amongst British urologists, particularly with reference to one instillation after resecting a new bladder tumour, hypothesizing that British urologists would use mitomycin C in line with current guidelines. A one-page questionnaire was mailed to 527 consultant urologists in the UK enquiring about their use of mitomycin C in superficial bladder cancer. A second mailing was sent to encourage nonresponders. Of the 527 consultants, 320 (61%) replied, of which 313 (59%) questionnaires were evaluable. Of these 313 respondents, 299 (95%) used mitomycin C; 244 respondents (82%) advocated the use of one dose of mitomycin C after resecting a new tumour, but only 10 (4%) would use it immediately after tumour resection and 155 (64%) use it within 24 h. Most (98%) respondents favoured the use of a mitomycin C course after resecting multiple tumours or after multiple recurrences. Interestingly, 20 respondents (7%) would use mitomycin C as a first-line therapy for carcinoma in situ and a further 23 (8%) woul...Continue Reading

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Citations

Sep 16, 2010·Urology Annals·Khalid Al-Othman, Naif Al-Hathal
Apr 22, 2009·Cancer·Michael A O'Donnell
Jan 21, 2017·Journal of Clinical Epidemiology·Melina L WillsonUNKNOWN Guidelines International Network Implementation Working Group
Apr 6, 2013·Urologia·Antonio Gerardo Curotto
Aug 24, 2006·Expert Review of Anticancer Therapy·Christian BolenzMaurice Stephan Michel

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