PMID: 9422563Jan 9, 1998Paper

Chemo-radiotherapy for localized pancreatic cancer: increased dose intensity and reduced acute toxicity with concomitant radiotherapy and protracted venous infusion 5-fluorouracil

International Journal of Radiation Oncology, Biology, Physics
J C PoenD R Goffinet

Abstract

Although concomitant radiation therapy (RT) and bolus 5-Fluorouracil (5-FU) have been shown to improve survival in locally confined pancreatic cancer, most patients will eventually succumb to their disease. Since 1994, we have attempted to improve efficacy by administering 5-FU as a protracted venous infusion (PVI). This study compares treatment intensity and acute toxicity of consecutive protocols of concurrent RT and 5-FU by bolus injection or PVI. Since 1986, 74 patients with resected or locally advanced pancreatic cancer were treated with continuous course RT and concurrent 5-FU by bolus injection (n = 44) or PVI throughout the course of RT (n = 30). Dose intensity was assessed for both 5-FU and radiotherapy. Toxicity endpoints which could be reliably and objectively quantified (e.g., neutropenia, weight loss, treatment interruption) were evaluated. Cumulative 5-FU dose (mean = 7.2 vs. 2.5 gm/m2, p < 0.001) and weekly 5-FU dose (mean = 1.3 vs. 0.5 gm/m2/wk, p < 0.001) were significantly higher for patients receiving PVI 5-FU. Following pancreaticoduodenectomy, 95% of PVI patients maintained a RT dose intensity of > or = 900 cGy/wk, compared with 63% of those receiving bolus 5-FU (p = 0.02). No difference was seen for patien...Continue Reading

References

Feb 1, 1991·International Journal of Radiation Oncology, Biology, Physics·S R SmalleyR G Evans
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J E ByfieldF Kulhanian
Feb 1, 1983·Journal of Surgical Oncology·R L DalesR S Davies
Jul 30, 1995·International Journal of Radiation Oncology, Biology, Physics·C A PerezM A Lockett
Mar 1, 1995·World Journal of Surgery·T A Rich, D B Evans
Mar 1, 1995·World Journal of Surgery·H O Douglass
May 5, 1994·The New England Journal of Medicine·W C WoodC R Ferree
Apr 1, 1996·International Journal of Radiation Oncology, Biology, Physics·M A CarducciL B Grochow
Apr 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M L RothenbergD D Von Hoff

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Citations

May 9, 2008·International Journal of Clinical Oncology·Takuji OkusakaHiroyuki Shinchi
Apr 9, 2002·Current Oncology Reports·Andrew H Ko, Margaret A Tempero
Jul 19, 2001·The Surgical Clinics of North America·R Wagman, A Grann
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·V K MehtaJ C Poen
Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·G BozM G Trovò
Dec 7, 2010·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·L MineurF Denis
Oct 4, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Frederik WenzFrank Lohr
Jul 16, 2005·Oncology·Chigusa MorizaneHiroshi Ikeda
May 16, 2000·Cancer Investigation·D J Klaassen
Aug 7, 2007·Seminars in Oncology·Mary F Mulcahy
Aug 7, 2007·Seminars in Oncology·Suzanne RussoA William Blackstock
Jul 9, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·F HuguetM Javle
Mar 10, 2001·International Journal of Cancer. Journal International Du Cancer·B D Minsky
Feb 25, 1999·Annals of Surgical Oncology·J C PoenJ E Niederhuber
Nov 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C J McGinnT S Lawrence
Apr 19, 2002·Chronobiology International·Tyvin A RichMartin Straume

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