Mar 1, 1987

Chemoattraction enrichment of thymus-homing bone marrow cells

Cell and Tissue Kinetics
J L HaarJ K Taubenberger

Abstract

It has been reported that a population of cells from mouse bone marrow migrates to supernatant made from the incubation of minced fragments of new-born mouse thymuses and that the migrated population is enriched for immature lymphoid cells. In the present study, we show that this method enriches for thymic-homing cells. Migration-enriched cells were labelled with fluorescein isothiocyanate (FITC) and were injected into the tail veins of lethally irradiated mice. Cell suspensions of the thymuses from these experimental mice had 8.1 +/- 1.8% fluorescing cells compared to control mice given equal numbers of non-migration-enriched FITC labelled cells which had 2.4 +/- 1.7% positive cells.

Mentioned in this Paper

Mice, Inbred CBA
Flow Cytometry
Positive Chemotaxis
Cell Motility
Neoplasm of Uncertain or Unknown Behavior of Thymus
Isothiocyanates
Lymphoid Cells
Fluorescein
Disease of Thymus Gland
Chemotaxis

About this Paper

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