Chemoenzymatic Production and Engineering of Chitooligosaccharides and N -acetyl Glucosamine for Refining Biological Activities

Frontiers in Chemistry
Manish KumarNidhi Pareek

Abstract

Chitooligosaccharides (COS) and N-acetyl glucosamine (GlcNAc) are currently of enormous relevance to pharmaceutical, nutraceutical, cosmetics, food, and agriculture industries due to their wide range of biological activities, which include antimicrobial, antitumor, antioxidant, anticoagulant, wound healing, immunoregulatory, and hypocholesterolemic effects. A range of methods have been developed for the synthesis of COS with a specific degree of polymerization along with high production titres. In this respect, chemical, enzymatic, and microbial means, along with modern genetic manipulation techniques, have been extensively explored; however no method has been able to competently produce defined COS and GlcNAc in a mono-system approach. Henceforth, the chitin research has turned toward increased exploration of chemoenzymatic processes for COS and GlcNAc generation. Recent developments in the area of green chemicals, mainly ionic liquids, proved vital for the specified COS and GlcNAc synthesis with better yield and purity. Moreover, engineering of COS and GlcNAc to generate novel derivatives viz. carboxylated, sulfated, phenolic acid conjugated, amino derived COS, etc., further improved their biological activities. Consequently,...Continue Reading

References

Apr 20, 2000·Enzyme and Microbial Technology·R S PatilM V Deshpande
Nov 7, 2006·Bioorganic & Medicinal Chemistry·Niranjan RajapakseSe-Kwon Kim
Feb 22, 2007·Journal of Agricultural and Food Chemistry·Javid S MojarradSamira Bourbour
Jun 19, 2010·Marine Drugs·Berit B AamVincent G H Eijsink
Oct 16, 2010·Marine Drugs·Jeen-Kuan ChenChao-Lin Liu
Dec 3, 2011·Applied Microbiology and Biotechnology·Lukas HartlVerena Seidl-Seiboth
Dec 6, 2011·Carbohydrate Research·Takeshi HattoriTaichi Usui
Mar 20, 2012·Journal of Enzyme Inhibition and Medicinal Chemistry·Tae-Kil EomSe-Kwon Kim
Jul 20, 2012·Environmental Toxicology and Pharmacology·Tae-Kil EomSe-Kwon Kim
Oct 13, 2012·International Journal of Biological Macromolecules·Xiaoyun LuYali Zhang
Apr 6, 2013·Journal of Pharmacy & Bioallied Sciences·Rifat HamidSaleem Javed
May 15, 2013·International Journal of Biological Macromolecules·Di ZhaoJunni Dong
Jul 19, 2013·Critical Reviews in Biotechnology·Anand NagpureRajinder K Gupta
Nov 26, 2013·Nucleic Acids Research·Vincent LombardBernard Henrissat
Feb 14, 2014·International Journal of Biological Macromolecules·Mai Duy Luu TrinhDai-Nghiep Ngo
Aug 16, 2014·Bioscience, Biotechnology, and Biochemistry·Paknisa SirimontreeTamo Fukamizo
Oct 30, 2014·Marine Drugs·Woo-Jin Jung, Ro-Dong Park
Dec 18, 2014·Green Chemistry : an International Journal and Green Chemistry Resource : GC·Helena PassosJoão A P Coutinho
Apr 7, 2015·International Journal of Biological Macromolecules·Yu-xia MeiYun-xiang Liang
Jul 16, 2015·Pharmaceutical Patent Analyst·Sneha ChoubeyVikas Beniwal
Nov 6, 2015·ChemSusChem·Mizuho YabushitaAtsushi Fukuoka
Jun 21, 2016·International Journal of Biological Macromolecules·Xing FuZhengqiang Jiang
Jun 28, 2016·Environmental Toxicology and Pharmacology·Sugyeong HongMoon-Moo Kim
Oct 14, 2016·International Journal of Molecular Sciences·Lidong CaoQiliang Huang
Apr 5, 2017·International Journal of Biological Macromolecules·Mitsuhiro UedaMinoru Sakaguchi
May 10, 2017·The Journal of Chemical Physics·F MaierH-P Steinrück
Sep 21, 2017·Carbohydrate Polymers·Lin YueWenshui Xia
Oct 27, 2017·Marine Drugs·Yao JiangZhengquan Su
Jan 22, 2018·Carbohydrate Polymers·Fakhra Liaqat, Rengin Eltem
Jan 24, 2018·Journal of Agricultural and Food Chemistry·Malgorzata KrolickaCarmen G Boeriu
May 2, 2018·The Journal of General and Applied Microbiology·Keitaro TakeMamoru Wakayama
May 22, 2018·International Journal of Biological Macromolecules·Manish KumarNidhi Pareek

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Datasets Mentioned

BETA
RC1830

Methods Mentioned

BETA
chemical treatment
transglycosylation
acetylation
ELISA
chemical treatments
NMR
glycosylation
electrophoresis
nuclear magnetic resonance
scanning electron microscopy

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