Chemoenzymatic synthesis of prodigiosin analogues--exploring the substrate specificity of PigC

Chemical Communications : Chem Comm
Suresh R ChawraiFinian J Leeper

Abstract

Analogues of prodigiosin, a tripyrrolic pigment produced by Serratia species with potent immunosuppressive and anticancer activities, have been produced by feeding synthetic analogues of the normal precursor MBC to mutants of Serratia sp. ATCC 39006 or to engineered strains of Escherichia coli; in this way it has been shown that the prodigiosin synthesising enzyme, PigC, has a relaxed substrate-specificity.

References

Jan 31, 1972·Biochemical and Biophysical Research Communications·W K TanakaW R Hearn
Apr 1, 1966·Journal of Bacteriology·D A Morrison
Feb 7, 1967·Biochimica Et Biophysica Acta·P P MukherjeeR P Williams
Jul 25, 2003·Advances in Applied Microbiology·J W Bennett, R Bentley
Sep 28, 2006·Journal of the American Chemical Society·Sylvie Garneau-TsodikovaChristopher T Walsh
Nov 17, 2006·Nature Reviews. Microbiology·Neil R WilliamsonGeorge P C Salmond
Nov 28, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mai NguyenGordon C Shore
Nov 29, 2007·Future Microbiology·Neil R WilliamsonGeorge P C Salmond

❮ Previous
Next ❯

Citations

Jun 18, 2016·Chemical Reviews·Dennis X HuRegan J Thomson
Dec 21, 2017·The ISME Journal·Andrew C PawlowskiGerard D Wright
Feb 15, 2019·Applied Microbiology and Biotechnology·Zhongyu YouWenjing Wu
Oct 16, 2019·Chembiochem : a European Journal of Chemical Biology·Katherine J PicottAvena C Ross
Jul 7, 2018·Beilstein Journal of Organic Chemistry·Sayantan BhaduriDev P Arya
Nov 11, 2019·Applied and Environmental Microbiology·Qingshan LongMeifeng Tao
Nov 20, 2020·ChemMedChem·Lea WinandMarkus Nett
Feb 18, 2021·Chemical Communications : Chem Comm·Stefanie BrandsUlrich Schwaneberg
Nov 5, 2020·ACS Chemical Biology·Tomasz ChilczukTimo Horst Johannes Niedermeyer
May 16, 2017·ACS Synthetic Biology·Andreas S KleinJörg Pietruszka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.