Chemoenzymatic synthesis of small molecule human therapeutics

Current Pharmaceutical Design
Ningqing RanJunhua Tao

Abstract

Pharmaceuticals have historically been produced by either chemical synthesis or whole cell fermentation. The former is applied to synthetic small molecules while the latter to natural products. As a result of recent advances in rapid discovery of enzymes through genome mining and metagenomics, and their tunability in functions and stability through directed evolution, biocatalysis is emerging to be a transformational technology for drug discovery and production. Enzymes can catalyze reactions otherwise challenging by chemical approaches. Furthermore, enzymatic catalysis is a powerful tool for green chemistry development. This manuscript gives a brief overview of current status in integrating chemical and biological transformations for the synthesis of small molecular therapeutics.

Citations

Aug 5, 2009·Applied Microbiology and Biotechnology·Sang-Hyun Lee, Oh-Jin Park
Aug 10, 2011·Journal of the American Chemical Society·Yousong DingDavid H Sherman
May 10, 2012·Journal of Biotechnology·Joachim JoseMark George Teese

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