Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis.

Journal of the American Society of Nephrology : JASN
Hans-Joachim AndersDetlef Schlöndorff

Abstract

Chemokines participate in leukocyte infiltration, which plays a major role in glomerular injury during immune complex glomerulonephritis (IC-GN). Because target cell expression of chemokine receptors (CCR) is thought to mediate leukocyte migration, the expression pattern of chemokines and CCR in a model of IC-GN was examined. The transient course and predominant glomerular pathology of this model allows the examination of both the induction and resolution phases of IC-GN. GN was induced in mice by daily apoferritin injection for 2 wk. Urine samples and kidneys were obtained at 1, 2, and 4 wk. Albuminuria was noted at 2 wk, but resolved after 4 wk. This was associated with glomerular IC deposits and mesangial proliferation. Glomerular macrophage infiltration was prominent at 1 and 2 wk, which resolved at 4 wk. Expression of monocyte chemoattractant protein-1 (MCP-1) and RANTES mRNA was upregulated at week 1 and decreased to control levels at weeks 2 and 4. The expression was localized to glomeruli by in situ hybridization and immunohistochemistry. The mRNA of CCR1, CCR2, and CCR5 but not CCR3 or CCR4 were upregulated at week 1 and decreased at weeks 2 and 4. Expression of CCR5 was located to the glomerulus by in situ hybridizati...Continue Reading

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Citations

Jan 23, 2003·Journal of the American Society of Nephrology : JASN·Hans-Joachim AndersHermann-Josef Gröne
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·Guillermo Pérez DE LemaDetlef Schlöndorff
Jan 12, 2002·Kidney International·Clemens D CohenMatthias Kretzler
Mar 13, 2003·Kidney International·Hans-Joachim AndersDetlef Schlöndorff
Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hans-Joachim AndersDetlef Schlöndorff
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