Chemokine and chemokine receptors in autoimmunity: the case of primary biliary cholangitis

Expert Review of Clinical Immunology
Jinjung ChoiM Eric Gershwin

Abstract

Chemokines represent a major mediator of innate immunity and play a key role in the selective recruitment of cells during localized inflammatory responses. Beyond critical extracellular mediators of leukocyte trafficking, chemokines and their cognate receptors are expressed by a variety of resident and infiltrating cells (monocytes, lymphocytes, NK cells, mast cells, and NKT cells). Chemokines represent ideal candidates for mechanistic studies (particularly in murine models) to better understand the pathogenesis of chronic inflammation and possibly become biomarkers of disease. Nonetheless, therapeutic approaches targeting chemokines have led to unsatisfactory results in rheumatoid arthritis, while biologics against pro-inflammatory cytokines are being used worldwide with success. In this comprehensive review we will discuss the evidence supporting the involvement of chemokines and their specific receptors in mediating the effector cell response, utilizing the autoimmune/primary biliary cholangitis setting as a paradigm.

References

Jun 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T F DeuelR L Heinrikson
Oct 1, 1991·The Journal of Clinical Investigation·W C DarbonneJ B Baker
Oct 1, 1987·The Journal of Experimental Medicine·A D Luster, J V Ravetch
Sep 1, 1988·The Journal of Experimental Medicine·A B GottliebD M Carter
Nov 10, 1995·The Journal of Biological Chemistry·R M StrieterD Marriott
Nov 1, 1995·The Journal of Experimental Medicine·F LiaoJ M Farber
May 1, 1995·Journal of Leukocyte Biology·I Clark-LewisB D Sykes
Jan 1, 1996·Journal of Leukocyte Biology·P ProostJ Van Damme
Feb 13, 1997·Nature·J F BazanT J Schall
Apr 4, 1998·The Journal of Experimental Medicine·F SallustoA Lanzavecchia
May 16, 1998·The Journal of Pathology·M GoebelerR Gillitzer
Oct 1, 1998·European Journal of Immunology·F SallustoA Lanzavecchia
Jan 14, 1999·Journal of Leukocyte Biology·C H Kim, H E Broxmeyer
Nov 11, 1999·European Journal of Immunology·B LuN P Gerard
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·O YonedaH Umehara
Jun 3, 2000·Annual Review of Immunology·D Rossi, A Zlotnik
Dec 9, 2000·The Journal of Biological Chemistry·P LoetscherI Clark-Lewis

❮ Previous
Next ❯

Citations

Jul 7, 2016·Mediators of Inflammation·Andrea SchnúrGuido Veit
Nov 23, 2017·Hepatology International·Ana LleoM Eric Gershwin
May 19, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Min LianXiong Ma
Mar 13, 2020·Frontiers in Immunology·Frida SommerAnnemarie H Meijer
Apr 4, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Atsushi Tanaka, M Eric Gershwin
Oct 24, 2017·Hepatology Communications·Atsushi TanakaaM Eric Gershwin
Nov 13, 2019·Clinical Reviews in Allergy & Immunology·Lixia GaoM Eric Gershwin
Mar 27, 2020·ImmunoTargets and Therapy·Noha Mousaad ElemamAzzam A Maghazachi
Mar 17, 2017·Journal of Immunology Research·Urszula WasikMałgorzata Milkiewicz
Aug 14, 2021·Frontiers in Cell and Developmental Biology·Sheng WangXiongwen Lv

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.